8hq2: Difference between revisions

Latest revision as of 14:43, 13 December 2023

Crystal structure of human ADAM22 in complex with human LGI1 mutantCrystal structure of human ADAM22 in complex with human LGI1 mutant

Structural highlights

8hq2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.93Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADA22_HUMAN Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.^[1] ^[2] ^[3]

References

↑ Zhu P, Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. Biochem Biophys Res Commun. 2003 Feb 21;301(4):991-9. PMID:12589811
↑ Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. Biochem Biophys Res Commun. 2005 Jun 17;331(4):938-46. PMID:15882968 doi:http://dx.doi.org/10.1016/j.bbrc.2005.03.229
↑ D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. Neurosurgery. 2006 Jan;58(1):179-86; discussion 179-86. PMID:16385342

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OCA

[1] Zhu P, Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. Biochem Biophys Res Commun. 2003 Feb 21;301(4):991-9. PMID:12589811

[2] Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. Biochem Biophys Res Commun. 2005 Jun 17;331(4):938-46. PMID:15882968 doi:http://dx.doi.org/10.1016/j.bbrc.2005.03.229

[3] D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. Neurosurgery. 2006 Jan;58(1):179-86; discussion 179-86. PMID:16385342

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8hq2 is ON HOLD
+==Crystal structure of human ADAM22 in complex with human LGI1 mutant==
+<StructureSection load='8hq2' size='340' side='right'caption='[[8hq2]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
-Authors: Liu, H., Lin, Z., Xu, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hq2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HQ2 FirstGlance]. <br>
-Description: Crystal structure of human ADAM22 in complex with human LGI1 mutant
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.93&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Xu, F]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hq2 OCA], [https://pdbe.org/8hq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hq2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hq2 ProSAT]</span></td></tr>
-[[Category: Lin, Z]]
+</table>
-[[Category: Liu, H]]
+== Function ==
+[https://www.uniprot.org/uniprot/ADA22_HUMAN ADA22_HUMAN] Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.<ref>PMID:12589811</ref> <ref>PMID:15882968</ref> <ref>PMID:16385342</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Lin Z]]
+[[Category: Liu H]]
+[[Category: Xu F]]

8hq2: Difference between revisions

Latest revision as of 14:43, 13 December 2023

Crystal structure of human ADAM22 in complex with human LGI1 mutantCrystal structure of human ADAM22 in complex with human LGI1 mutant

Structural highlights

Function

References

Contents

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8hq2: Difference between revisions

Latest revision as of 14:43, 13 December 2023

Crystal structure of human ADAM22 in complex with human LGI1 mutantCrystal structure of human ADAM22 in complex with human LGI1 mutant

Structural highlights

Function

References

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