8f80: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8f80 is ON HOLD  until Paper Publication
==Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738==
 
<StructureSection load='8f80' size='340' side='right'caption='[[8f80]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8f80]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_ulcerans_Agy99 Mycobacterium ulcerans Agy99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F80 FirstGlance]. <br>
Description: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=XJB:3-[2-(3-{[2,4-diamino-6-(4-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic+acid'>XJB</scene></td></tr>
[[Category: Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f80 OCA], [https://pdbe.org/8f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f80 RCSB], [https://www.ebi.ac.uk/pdbsum/8f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0PQG8_MYCUA A0PQG8_MYCUA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium ulcerans Agy99]]
[[Category: Structural genomic]]

Latest revision as of 14:39, 13 December 2023

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738

Structural highlights

8f80 is a 1 chain structure with sequence from Mycobacterium ulcerans Agy99. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0PQG8_MYCUA Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]

8f80, resolution 1.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=8f80&oldid=3979729"