Succinate-semialdehyde dehydrogenase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code [[3vz3]]).' scene='59/590825/Cv/2'>
-<StructureSection load='3vz3' size='340' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code [[3vz3]]).' scene=''>
+== Function ==
-== Function ==
+'''Succinate-semialdehyde dehydrogenase''' or '''α-ketoglutaric semialdehyde dehydrogenase''' or '''succinyl-CoA reductase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+.  SSD participates in glutamate and butyrate metabolism<ref>PMID:13654295</ref>. See also [[Aldehyde dehydrogenase]].
-'''Succinate-semialdehyde dehydrogenase''' (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+.  SSD participates in glutamate and butyrate metabolism.
 == Disease ==
-== Relevance ==
+SSD deficiency is a disorder of GABA metabolism with symptoms of seizures, delayed development and hypotonia<ref>PMID:15341910</ref>.
 == Structural highlights ==
+The active site of SSD contains the <scene name='59/590825/Cv/4'>substrate succinate semialdehyde</scene> and the <scene name='59/590825/Cv/11'>cofactor NADP</scene><ref>PMID:23500184</ref>. Water molecules are shown as red spheres. <scene name='59/590825/Cv/12'>Whole binding site</scene>.
+</StructureSection>
 ==3D structures of succinate-semialdehyde dehydrogenase==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*Succinate-semialdehyde dehydrogenase
-[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
+**[[2w8n]], [[2w8o]] – hSSD - human <br />
-[[3vz2]] – SySSD (mutant) <br />
+**[[2w8p]] – hSSD (mutant) <br />
-[[3ifg]], [[3ifh]] – SSD – ''Burkholderia pseudomallei''<br />
+**[[4it9]], [[3vz1]] – SySSD - ''Synechococcus''<br />
-[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
+**[[3vz2]] – SySSD (mutant) <br />
-[[2w8n]], [[2w8o]] – hSSD - human <br />
+**[[4v6h]] – SSD – ''Burkholderia pseudomallei''<br />
-[[2w8p]] – hSSD (mutant) <br />
+**[[5vbf]] – SSD – ''Burkholderia vietnamiensis''<br />
+**[[3rh9]] – SSD – ''Marinobacter aquaeolei''<br />
+**[[4ogd]] – SpSSD – ''Streptococcus pyogenes'' <br />
+**[[5x5t]] – AbSSD – ''Azuspirillum brasilense'' <br />
-'''Succinate-semialdehyde dehydrogenase complexes'''
+*Succinate-semialdehyde dehydrogenase complexes
-[[2w8q]] – hSSD (mutant) + succinate<br />
+**[[2w8q]] – hSSD (mutant) + succinate<br />
-[[2w8r]] – hSSD (mutant) + ADP<br />
+**[[2w8r]] – hSSD (mutant) + ADP<br />
-[[4ita]] – SySSD + NADPH<br />
+**[[4ita]] – SySSD + NADPH<br />
-[[4itb]] – SySSD + NADPH + succinic semialdehyde<br />
+**[[4itb]] – SySSD + NADPH + succinic semialdehyde<br />
-[[3vz3]] – SySSD (mutant) + NADPH + succinic semialdehyde<br />
+**[[3vz3]] – SySSD (mutant) + NADPH + succinic semialdehyde<br />
-[[3jz4]] – SSD + NADPH – ''Escherichia coli''<br />
+**[[3jz4]] – SSD + NADPH – ''Escherichia coli''<br />
+**[[4oht]] – SpSSD + NADPH<br />
+**[[4ywu]], [[4ywv]] – SySSD + oxobutanoic acid + succinic semialdehyde<br />
+**[[5x5u]] – AbSSD + NAD<br />
+**[[8c54]] – SSD + NADH – ''Rhizobium leguminosarum'' – Cryo EM<br />
+**[[8cej]] – CkSSD + mesaconyl-c1-CoA – ''Clostridium kluyveri''<br />
+**[[8cek]] – CkSSD + NADPH<br />
+}}
 == References ==