1zbn: Difference between revisions

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OCA

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 ==Solution structure of BIV TAR hairpin complexed to JDV Tat arginine-rich motif==
-<StructureSection load='1zbn' size='340' side='right' caption='[[1zbn]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1zbn' size='340' side='right'caption='[[1zbn]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zbn]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZBN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zbn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Jembrana_disease_virus Jembrana disease virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZBN FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1biv|1biv]], [[1mnb|1mnb]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zbn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zbn RCSB], [http://www.ebi.ac.uk/pdbsum/1zbn PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zbn OCA], [https://pdbe.org/1zbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zbn RCSB], [https://www.ebi.ac.uk/pdbsum/1zbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zbn ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TAT_JEMBR TAT_JEMBR] Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. Tat binds to a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) in a CCNT1-independent mode. Tat then recruits the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. The CDK9 component of P-TEFb hyperphosphorylates the C-terminus of RNA Pol II that becomes stabilized and much more processive (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1zbn" style="background-color:#fffaf0;"></div>
 ==See Also==
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 __TOC__
 </StructureSection>
-[[Category: Calabro, V.]]
+[[Category: Jembrana disease virus]]
-[[Category: Daugherty, M D.]]
+[[Category: Large Structures]]
-[[Category: Frankel, A D.]]
+[[Category: Calabro V]]
-[[Category: Rna binding protein-rna complex]]
+[[Category: Daugherty MD]]
-[[Category: Rna-peptide complex]]
+[[Category: Frankel AD]]