1wm7: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1wm7.jpg|left|200px]]
- {{Structure
+==Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures==
-|PDB= 1wm7 |SIZE=350|CAPTION= <scene name='initialview01'>1wm7</scene>
+<StructureSection load='1wm7' size='340' side='right'caption='[[1wm7]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1wm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WM7 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wm7 OCA], [https://pdbe.org/1wm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wm7 ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KAX82_MESMA KAX82_MESMA] Blocks small conductance calcium-activated potassium channels (KCNN, SK). Low toxicity by intracerebroventricular injection into mice.<ref>PMID:22511981</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem. 245, 457-464). It was shown to reduce 33% outward K(+) channel (hippocampal neurons) currents at 10 microM. The solution structure of BmP01 was determined by 2D (1)H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmP01 is composed of a short alpha-helix (Cys 3-Thr 12) and a two-stranded antiparallel beta-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disulfide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting the alpha-helix and beta-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison between BmP01 and its analogues are also presented.
-'''Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures'''
+Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch.,Wu G, Li Y, Wei D, He F, Jiang S, Hu G, Wu H Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. PMID:11027603<ref>PMID:11027603</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1wm7" style="background-color:#fffaf0;"></div>
-==Overview==
+==See Also==
-From the venom of scorpion Buthus martensii Karsch,a short peptide (BmP01, 29 amino acid residues) was isolated and characterized as previously reported (Lebren, R. R., et al. (1997) Eur. J. Biochem. 245, 457-464). It was shown to reduce 33% outward K(+) channel (hippocampal neurons) currents at 10 microM. The solution structure of BmP01 was determined by 2D (1)H NMR spectroscopy. The NOEs, coupling constants, and H-D exchange obtained from NMR spectroscopy were used in structural calculations. The conformation of BmP01 is composed of a short alpha-helix (Cys 3-Thr 12) and a two-stranded antiparallel beta-sheet (Ala 15-Asp 20 and Lys 23-Pro 28). There are three disulfide bridges (Cys 3-Cys 19, Cys 6-Cys 24 and Cys 10-Cys 26) connecting the alpha-helix and beta-sheet. Asp 20 to Lys 23 form a type II turn linking the two strands. Structural and electrostatic potential comparison between BmP01 and its analogues are also presented.
+*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-WM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM7 OCA].
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-Solution structure of BmP01 from the venom of scorpion Buthus martensii Karsch., Wu G, Li Y, Wei D, He F, Jiang S, Hu G, Wu H, Biochem Biophys Res Commun. 2000 Oct 5;276(3):1148-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11027603 11027603]
 [[Category: Mesobuthus martensii]]
-[[Category: Single protein]]
+[[Category: Chen X]]
-[[Category: Chen, X.]]
+[[Category: He F]]
-[[Category: He, F.]]
+[[Category: Hu G]]
-[[Category: Hu, G.]]
+[[Category: Jiang S]]
-[[Category: Jiang, S.]]
+[[Category: Li Y]]
-[[Category: Li, Y.]]
+[[Category: Wei D]]
-[[Category: Wei, D.]]
+[[Category: Wu G]]
-[[Category: Wu, G.]]
+[[Category: Wu H]]
-[[Category: Wu, H.]]
-[[Category: alpha/beta scaffold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:58:53 2008''