1qh2: Difference between revisions

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-[[Image:1qh2.jpg|left|200px]]
- {{Structure
+==CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA==
-|PDB= 1qh2 |SIZE=350|CAPTION= <scene name='initialview01'>1qh2</scene>
+<StructureSection load='1qh2' size='340' side='right'caption='[[1qh2]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1qh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QH2 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [https://pdbe.org/1qh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qh2 ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [http://www.ebi.ac.uk/pdbsum/1qh2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB]</span>
+[https://www.uniprot.org/uniprot/Q40378_NICAL Q40378_NICAL]
-}}
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
-'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''
+A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.,Lee MC, Scanlon MJ, Craik DJ, Anderson MA Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353<ref>PMID:10360353</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1qh2" style="background-color:#fffaf0;"></div>
-==Overview==
+==See Also==
-Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
+*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360353 10360353]
 [[Category: Nicotiana alata]]
-[[Category: Protein complex]]
+[[Category: Anderson MA]]
-[[Category: Anderson, M A.]]
+[[Category: Craik DJ]]
-[[Category: Craik, D J.]]
+[[Category: Lee MCS]]
-[[Category: Lee, M C.S.]]
+[[Category: Scanlon MJ]]
-[[Category: Scanlon, M J.]]
-[[Category: nicotiana alata]]
-[[Category: potato ii trypsin inhibitor]]
-[[Category: proteinase inhibitor (chymotrypsin)]]
-[[Category: serine proteinase inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:28 2008''