2he8: Difference between revisions
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<StructureSection load='2he8' size='340' side='right'caption='[[2he8]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2he8' size='340' side='right'caption='[[2he8]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2he8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2he8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HE8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he8 OCA], [https://pdbe.org/2he8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he8 RCSB], [https://www.ebi.ac.uk/pdbsum/2he8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2he8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he8 OCA], [https://pdbe.org/2he8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2he8 RCSB], [https://www.ebi.ac.uk/pdbsum/2he8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2he8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AK1CL_MOUSE AK1CL_MOUSE] NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids.<ref>PMID:15577209</ref> <ref>PMID:16018803</ref> <ref>PMID:17034817</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Breton | [[Category: Breton R]] | ||
[[Category: Cantin | [[Category: Cantin L]] | ||
[[Category: Faucher | [[Category: Faucher F]] | ||
[[Category: Labrie F]] | |||
[[Category: Labrie | [[Category: Luu-the V]] | ||
[[Category: Luu-the | [[Category: Pereira de Jesus-Tran K]] | ||
[[Category: | |||