1e2h: Difference between revisions

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-==THE NUCLEOSIDE BINDING SITE OF HERPES SIMPLEX TYPE 1 THYMIDINE KINASE ANALYZED BY X-RAY CRYSTALLOGRAPHY==
-<StructureSection load='1e2h' size='340' side='right' caption='[[1e2h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+==The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography==
+<StructureSection load='1e2h' size='340' side='right'caption='[[1e2h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1e2h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1e2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2H FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kim|1kim]], [[1vtk|1vtk]], [[2vtk|2vtk]], [[3vtk|3vtk]], [[1ki2|1ki2]], [[1ki4|1ki4]], [[1ki5|1ki5]], [[1ki6|1ki6]], [[1ki7|1ki7]], [[1ki8|1ki8]], [[1e2i|1e2i]], [[1e2j|1e2j]], [[1e2k|1e2k]], [[1e2l|1e2l]], [[1e2m|1e2m]], [[1e2n|1e2n]], [[1e2p|1e2p]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2h OCA], [https://pdbe.org/1e2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2h RCSB], [https://www.ebi.ac.uk/pdbsum/1e2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2h ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e2h RCSB], [http://www.ebi.ac.uk/pdbsum/1e2h PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2h_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/1e2h_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e2h ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1e2h" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Herpes Simplex Virus Thymidine Kinase|Herpes Simplex Virus Thymidine Kinase]]
+*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
-*[[Thymidine kinase|Thymidine kinase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Thymidine kinase]]
+[[Category: Human alphaherpesvirus 1 strain 17]]
-[[Category: Scapozza, L]]
+[[Category: Large Structures]]
-[[Category: Schulz, G E]]
+[[Category: Scapozza L]]
-[[Category: Vogt, J]]
+[[Category: Schulz GE]]
-[[Category: Adenine analog]]
+[[Category: Vogt J]]
-[[Category: Enzyme-prodrug gene therapy]]
-[[Category: Nucleoside- binding]]
-[[Category: Transferase]]