Stathmin: Difference between revisions

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<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions  (PDB code [[3ryf]])' scene=''>
<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions  (PDB code [[3ryf]])' scene=''>
== Function ==
== Function ==
'''Stathmin-4''' (STM-4) regulates microtubules dynamics.  Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton.  STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly.  Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle.  Thus, STM-4 is an oncoprotein.  STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>.
'''Stathmin-4''' (STM-4) or '''stathmin-like protein B3''' regulates microtubules dynamics.  Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton.  STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly.  Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle.  Thus, STM-4 is an oncoprotein.  STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>.


== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>


== 3D Structures of stathmin-4 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Stathmin SLD domain complex with tubulin
**[[3ryf]] – rSTM + tubulin + GTP - rat<br />
**[[3hkb]], [[3ryc]], [[3ryi]] – rSTM + tubulin + GTP + GDP <br />
**[[3ryh]] – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate <br />
**[[3hkc]], [[3n2g]], [[3n2k]] – rSTM + tubulin + GTP + GDP + pyridine derivative <br />
**[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br />
**[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br />
**[[6h9b]] – rSTM + tubulin + GTP + GDP + quinoline derivative <br />
*Stathmin SLD domain complex with tubulin and drugs
**[[1sa0]] – rSTM + tubulin + GTP + GDP + anti-gout drug <br />
**[[1sa1]], [[1z2b]] – rSTM + tubulin + GTP + GDP + anti-wart drug <br />
**[[4eb6]], [[5j2u]] – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug <br />
**[[3du7]] – rSTM + tubulin + GTP + GDP + phomopsine + anti-gout drug  <br />
**[[3e22]] – rSTM + tubulin + GTP + GDP + soblidotine + anti-gout drug  <br />
**[[5lp6]], [[5kx5]] – rSTM + tubulin + GTP + GDP + drug <br />
**[[3ut5]] – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + anti-gout drug + Vinca tetrapeptide<br />
*Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase
**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br />
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br />
**[[5jqg]], [[6i5c]], [[4i55]], [[5xp3]], [[6jcj]], [[6gze] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br />
**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]], [[5o7a]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br />
**[[5ov7]] – rSTM + tubulin + protein + GTP + GDP + ACP + inhibitor<br />
**[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br />
**[[4o2a]], [[6k9vj]], [[6o5m]], [[6o5n]], [[6o61]], [[6qqn]], [[6agk]], [[5z4u]], [[5z4p]], [[5xi7]], [[5xi5]], [[5xhc]], [[5h7o]], [[6qtn]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br />
**[[6hx8]], [[6eg5]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + quinoline derivative<br />
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br />
**[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br />
**[[5lyj]], [[5mf4]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + natural product<br />
*Stathmin SLD domain complex with tubulin, tubulin tyrosine ligase and drug
**[[5xiw]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + anti-gout drug <br />
**[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug<br />
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br />
**[[5xkh]], [[5h74]], [[5gon]], [[5ezy]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br />
**[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]], [[4i50]], [[6knzj]], [[6n47]], [[6nng]], [[6gj4]], [[6gf3]], [[6f7c]], [[5zxh]], [[5yz3]], [[5xag]], [[5xaf]], [[5osk]], [[5ng1]], [[5nfz]], [[5jcb]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 14:02, 4 December 2023

Function

Stathmin-4 (STM-4) or stathmin-like protein B3 regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer[1].

Disease

Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease[2].

3D Structures of stathmin-4

Stathmin-4 3D structures


Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Curmi PA, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Struct Funct. 1999 Oct;24(5):345-57. PMID:15216892
  2. ↑ Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;(61):281-8. PMID:11771751

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Michal Harel, Joel L. Sussman
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