Stathmin: Difference between revisions

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<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions  (PDB code [[3ryf]])' scene=''>
<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions  (PDB code [[3ryf]])' scene=''>
== Function ==
== Function ==
'''Stathmin''' (STM) regulates microtubules dynamics.  Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton.  STM binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly.  Phosphorylation of STM weakens the binding of STM to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle.  Thus, STM is an oncoprotein.  STM contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>.
'''Stathmin-4''' (STM-4) or '''stathmin-like protein B3''' regulates microtubules dynamics.  Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton.  STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly.  Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle.  Thus, STM-4 is an oncoprotein.  STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>.


== Disease ==
== Disease ==
Decreased levels of STM are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>.
Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>.
 
== 3D Structures of stathmin-4 ==
[[Stathmin-4 3D structures]]


</StructureSection>
</StructureSection>


== 3D Structures of stathmin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Stathmin SLD domain complex with tubulin
**[[3ryf]] – rSTM + tubulin + GTP - rat<br />
**[[3hkb]], [[3ryc]], [[3ryi]] – rSTM + tubulin + GTP + GDP <br />
**[[3ryh]] – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate <br />
**[[3hkc]], [[3n2g]], [[3n2k]] – rSTM + tubulin + GTP + GDP + pyridine derivative <br />
**[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br />
**[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br />
*Stathmin SLD domain complex with tubulin and drugs
**[[1sa0]] – rSTM + tubulin + GTP + GDP + anti-gout drug <br />
**[[1sa1]], [[1z2b]] – rSTM + tubulin + GTP + GDP + anti-wart drug <br />
**[[4eb6]], [[5j2u]] – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug <br />
**[[3du7]] – rSTM + tubulin + GTP + GDP + phomopsine + anti-gout drug  <br />
**[[3e22]] – rSTM + tubulin + GTP + GDP + soblidotine + anti-gout drug  <br />
**[[5lp6]], [[5kx5]] – rSTM + tubulin + GTP + GDP + drug <br />
**[[3ut5]] – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + anti-gout drug + Vinca tetrapeptide<br />
*Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase
**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br />
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br />
**[[5jqg]], [[4wbn]], [[4i55]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br />
**[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br />
**[[4i50]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + epothilone <br />
**[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br />
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br />
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br />
**[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br />
**[[5lyj]], [[5mf4]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + natural product<br />
**[[5o7a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + quinolin derivative<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 14:02, 4 December 2023

Function

Stathmin-4 (STM-4) or stathmin-like protein B3 regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer[1].

Disease

Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease[2].

3D Structures of stathmin-4

Stathmin-4 3D structures


Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Curmi PA, Gavet O, Charbaut E, Ozon S, Lachkar-Colmerauer S, Manceau V, Siavoshian S, Maucuer A, Sobel A. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Struct Funct. 1999 Oct;24(5):345-57. PMID:15216892
  2. ↑ Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;(61):281-8. PMID:11771751

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Michal Harel, Joel L. Sussman
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