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| <StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> | | <StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> |
| '''Stathmin''' (STM) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM weakens the binding of STM to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM is an oncoprotein. STM contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer.
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| == Function == | | == Function == |
| | '''Stathmin-4''' (STM-4) or '''stathmin-like protein B3''' regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM-4 binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM-4 weakens the binding of STM-4 to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM-4 is an oncoprotein. STM-4 contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>. |
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| == Disease == | | == Disease == |
| | Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. |
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| == Relevance == | | == 3D Structures of stathmin-4 == |
| | | [[Stathmin-4 3D structures]] |
| == Structural highlights ==
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| </StructureSection> | | </StructureSection> |
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| == 3D Structures of stathmin ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Stathmin SLD domain complex with tubulin
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| **[[3ryf]] – rSTM + tubulin + GTP - rat<br />
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| **[[3hkb]], [[3ryc]], [[3ryi]] – rSTM + tubulin + GTP + GDP <br />
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| **[[3ryh]] – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate <br />
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| **[[3hkc]], [[3n2g]], [[3n2k]] – rSTM + tubulin + GTP + GDP + pyridine derivative <br />
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| **[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br />
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| **[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br />
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| *Stathmin SLD domain complex with tubulin and drugs
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| **[[1sa0]] – rSTM + tubulin + GTP + GDP + anti-gout drug <br />
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| **[[1sa1]], [[1z2b]] – rSTM + tubulin + GTP + GDP + anti-wart drug <br />
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| **[[4eb6]] – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug <br />
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| **[[3du7]] – rSTM + tubulin + GTP + GDP + phomopsine + colchicine <br />
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| **[[3e22]] – rSTM + tubulin + GTP + GDP + soblidotine + colchicine <br />
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| **[[3ut5]] – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + colchicine + Vinca tetrapeptide<br />
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| *Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase
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| **[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br />
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| **[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br />
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| **[[4wbn]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate <br />
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| **[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br />
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| **[[4i4t]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + zampanolide <br />
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| **[[4i50]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + epothilone <br />
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| **[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + anti-cancer drugs<br />
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| **[[4i55]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate <br />
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| **[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-gout drug<br />
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| **[[4o4h]], [[4o4j]], [[4o4i]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-cancer drug<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| | [[Category:Topic Page]] |