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| ==Your Heading Here (maybe something like 'Structure')==
| | <StructureSection load='3kbh' size='340' side='right' caption='Human coronavirus NL63 spike glycoprotein (magenta) complex with its ligand ACE2 (green) (PDB code [[3kbh]])' scene='84/840522/Cv/2'> |
| <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | |
| This is a default text for your page '''Spike protein'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
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| You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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| == Function == | | == Function == |
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| | The coronavirus '''spike protein''' (Spi, also called ''protein S'') binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus <ref>PMID:32075877</ref>. See also |
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| | *[[Angiotensin-Converting Enzyme#ACEII and SARS|ACEII and SARS]]<br /> |
| | *[[SARS-CoV-2 protein S]]<br /> |
| | *[[SARS-CoV-2 spike protein mutations]]<br /> |
| | *[[Coronavirus Disease 2019 (COVID-19)]]<br /> |
| | * and the animation at [[SARS-CoV-2 protein S priming by furin]] and [[SARS-CoV-2 spike protein fusion transformation]] |
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| == Disease == | | == Disease == |
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| | Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. |
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| == Relevance == | | == Relevance == |
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| | The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment<ref>PMID:32065055</ref>. |
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| == Structural highlights == | | == Structural highlights == |
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| This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
| | The SARS-CoV Spi receptor binding domain complex with its cellular receptor - ACE2 - shows the <scene name='84/840522/Cv/3'>interactions</scene> to ACE2 "hot spot"<ref>PMID:19901337</ref>. |
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| </StructureSection>
| | == See Also == |
| | *[[SARS-CoV-2 protein S]] |
| | *[[SARS-CoV-2 protein S priming by furin]] where the priming step induced by furin cleavage is '''animated'''. |
| | *[[SARS-CoV-2 spike protein fusion transformation]] with an '''animation''' and explanation of the membrane fusion mechanism. |
| | *[[SARS-CoV-2 spike protein mutations]] |
| | *[[Coronavirus Disease 2019 (COVID-19)]] |
| | *[[User:Andre Wu Le Chun/Sandbox 1|Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up]] about [[6vsb]] |
| | *[[Spike Protein (Hebrew)]] |
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| == 3D Structures of spike protein == | | == 3D Structures of spike protein == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[Spike protein 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Flagellin
| | == References == |
| | | <references/> |
| **[[5wrg]], [[5xlr]] – hscvSpi – human SARS coronavirus – Cryo EM <br />
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| **[[6crv]], [[6crw]], [[6crx]], [[6crz]], [[6cs0]], [[6cs1]] – hscvSpi (mutant) – Cryo EM <br />
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| **[[1wnc]] – hscvSpi fusion core 900-1184<br />
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| **[[2ghv]] – hscvSpi RBD 318-510<br />
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| **[[1wyy]] – hscvSpi 885-1189<br />
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| **[[1zv7]], [[1zv8]], [[1zva]], [[1zvb]] – hscvSpi 1150-1193<br />
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| **[[2ajf]] – hscvSpi RBD + ACHE<br />
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| **[[2ghw]], [[3bgf]], [[2dd8]] – hscvSpi RBD + antibody<br />
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| **[[6u7h]] – hcv229Spi – human coronavirus 229E – Cryo EM <br />
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| **[[6atk]] – hcv229Spi RBD + aminopeptidase <br />
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| **[[5x58]], [[5x5b]] – Spi – human SARS coronavirus BJ01 – Cryo EM <br />
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| **[[6vsb]], [[6vxx]], [[6vyb]] – hsc2Spi – human SARS coronavirus 2 – Cryo EM <br />
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| **[[6m0j]] – hsc2Spi RBD + ACE2<br />
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| **[[5szs]] – hcnSpi – human coronavirus NL63 - Cryo EM<br />
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| **[[2ieq]] – hcnSpi residues 981-1038, 1242-1283 <br />
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| **[[6cv0]] – Spi – infectious bronchitis coronavirus – Cryo EM <br />
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| **[[5fyn]] – Spi ectodomain - puumala virus - Cryo EM<br />
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| **[[5x59]], [[5x5c]], [[5x5f]] – McvSpi – MERS coronavirus virus – Cryo EM <br />
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| **[[5x4r]], [[5x4s]] – McvSpi N-terminal – Cryo EM <br />
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| **[[4zpw]], [[4kqz]] – McvSpi RBD<br />
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| **[[4kr0]] – McvSpi RBD + CD26<br />
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| **[[6pz8]] – McvSpi + antibody – Cryo EM <br />
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| **[[6j11]] – McvSpi N-terminal + antibody<br />
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| **[[4h14]] – Spi lectin domain 7-290 - bovine coronavirus<br />
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| **[[6b7n]] – Spi – porcine delta coronavirus – Cryo EM <br />
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| **[[6u7k]], [[6vv5]] – Spi – porcine epidemic diarrhea virus – Cryo EM <br />
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| **[[6qfy]] – Spi lectin domain 15-300 - porcine hemagglutinating encephalomyelitis virus<br />
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| **[[6jhy]] – Spi N-terminal – camel coronavirus HKU23<br />
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| **[[6jx7]] – Spi – feline infectious peritonitis virus – Cryo EM <br />
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| **[[1wdf]], [[1wdg]] – mhvSpi – murine hepatitis virus<br />
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| **[[3jcl]] – mhvSpi – Cryo EM<br />
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| **[[6vsj]] – mcvSpi + MHV-R – murine coronavirus - Cryo EM<br />
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| **[[6b3o]] – mcvSpi residues 718-1252 - Cryo EM<br />
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| **[[5gyq]] – bcvSpi RBD - bat coronavirus<br />
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| **[[5xgr]] – bcvSpi C-terminal<br />
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| **[[6orj]] – Spi - Pseudomonas virus phikz164i<br />
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| **[[2vvd]], [[2vve]] – Spi RBD - Pseudoalteromonas phage PM2<br />
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| **[[3aqj]] – Spi 87-211 - Enterobacteria phage P2<br />
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| }}
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| | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
| == References ==
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| <references/>
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