1nyj: Difference between revisions

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 ==The closed state structure of M2 protein H+ channel by solid state NMR spectroscopy==
-<StructureSection load='1nyj' size='340' side='right' caption='[[1nyj]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1nyj' size='340' side='right'caption='[[1nyj]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nyj]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NYJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nyj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/USSR/90/1977(H1N1)) Influenza A virus (A/USSR/90/1977(H1N1))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYJ FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mp6|1mp6]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nyj RCSB], [http://www.ebi.ac.uk/pdbsum/1nyj PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyj OCA], [https://pdbe.org/1nyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyj RCSB], [https://www.ebi.ac.uk/pdbsum/1nyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyj ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/M2_I77AB M2_I77AB] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1nyj" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Avian Influenza Neuraminidase%2C Tamiflu and Relenza|Avian Influenza Neuraminidase%2C Tamiflu and Relenza]]
+*[[Ion channels 3D structures|Ion channels 3D structures]]
-*[[Ion channels|Ion channels]]
-*[[M2 Proton Channel|M2 Proton Channel]]
 *[[M2 protein|M2 protein]]
 == References ==
@@ Line 24: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Cross, T A]]
+[[Category: Large Structures]]
-[[Category: Kim, S]]
+[[Category: Cross TA]]
-[[Category: Nishimura, K]]
+[[Category: Kim S]]
-[[Category: Zhang, L]]
+[[Category: Nishimura K]]
-[[Category: Influenza a virus]]
+[[Category: Zhang L]]
-[[Category: M2 proton channel]]
-[[Category: Membrane protein structure]]
-[[Category: Solid state nmr]]
-[[Category: Viral protein]]