7xao: Difference between revisions

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-'''Unreleased structure'''
-The entry 7xao is ON HOLD
+==Crystal structure of thioredoxin 1==
+<StructureSection load='7xao' size='340' side='right'caption='[[7xao]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7xao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XAO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xao OCA], [https://pdbe.org/7xao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xao RCSB], [https://www.ebi.ac.uk/pdbsum/7xao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xao ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/V5VGM8_ACIBA V5VGM8_ACIBA]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Thioredoxin (Trx) is a central component of the redox control system that maintains the redox homeostasis critical for organism survival. Owing to its central role in survival, Trx is a prospective target for novel antimicrobial agents. Herein, we report a 1.45 A high-resolution structure of Trx1 of Acinetobacter baumannii (abTrx1), an antibiotic-resistant pathogenic superbug. Although abTrx1 exhibited the canonical Trx fold, which consists of a four-stranded beta-sheet surrounded by four alpha-helices, structural differences were detected in the loop forming the C-X-X-C redox center and the C-terminal. The unique CAPC sequence of the C-X-X-C motif in the abTrx1 redox center was characterized by mutagenesis. This study contributes to the field of drug designing against superbugs.
-Authors:
+High-resolution crystal structure of Acinetobacter baumannii thioredoxin 1.,Chang YJ, Park HH Biochem Biophys Res Commun. 2022 Jun 11;608:1-7. doi: 10.1016/j.bbrc.2022.03.134. , Epub 2022 Mar 28. PMID:35378360<ref>PMID:35378360</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 7xao" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Acinetobacter baumannii]]
+[[Category: Large Structures]]
+[[Category: Chang YJ]]
+[[Category: Park HH]]