7vbt: Difference between revisions

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'''Unreleased structure'''


The entry 7vbt is ON HOLD  until 2023-09-01
==Crystal structure of RIOK2 in complex with CQ211==
<StructureSection load='7vbt' size='340' side='right'caption='[[7vbt]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7vbt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5400147&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ZH:8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one'>5ZH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vbt OCA], [https://pdbe.org/7vbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vbt RCSB], [https://www.ebi.ac.uk/pdbsum/7vbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vbt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIOK2_HUMAN RIOK2_HUMAN] Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).<ref>PMID:16037817</ref> <ref>PMID:19564402</ref> <ref>PMID:21880710</ref>


Authors: Zhu, C., Zhang, Z.M.
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
Description: Crystal structure of RIOK2 in complex with CQ211
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Zhu, C]]
__TOC__
[[Category: Zhang, Z.M]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zhang ZM]]
[[Category: Zhu C]]

Latest revision as of 20:22, 29 November 2023

Crystal structure of RIOK2 in complex with CQ211Crystal structure of RIOK2 in complex with CQ211

Structural highlights

7vbt is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5400147Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIOK2_HUMAN Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).[1] [2] [3]

See Also

References

  1. ↑ Rouquette J, Choesmel V, Gleizes PE. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J. 2005 Aug 17;24(16):2862-72. doi: 10.1038/sj.emboj.7600752. Epub 2005 Jul , 28. PMID:16037817 doi:http://dx.doi.org/10.1038/sj.emboj.7600752
  2. ↑ Zemp I, Wild T, O'Donohue MF, Wandrey F, Widmann B, Gleizes PE, Kutay U. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. J Cell Biol. 2009 Jun 29;185(7):1167-80. PMID:19564402 doi:http://dx.doi.org/jcb.200904048
  3. ↑ Liu T, Deng M, Li J, Tong X, Wei Q, Ye X. Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. J Biol Chem. 2011 Oct 21;286(42):36352-60. doi: 10.1074/jbc.M111.250175. Epub, 2011 Aug 31. PMID:21880710 doi:http://dx.doi.org/10.1074/jbc.M111.250175

7vbt, resolution 2.54Å

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