7e3m: Difference between revisions
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==== | ==RORgamma LBD complexed with Panaxatriol and SRC2.2== | ||
<StructureSection load='7e3m' size='340' side='right'caption='[[7e3m]]' scene=''> | <StructureSection load='7e3m' size='340' side='right'caption='[[7e3m]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7e3m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E3M FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e3m OCA], [https://pdbe.org/7e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e3m RCSB], [https://www.ebi.ac.uk/pdbsum/7e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e3m ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HVL:(3R,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol'>HVL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e3m OCA], [https://pdbe.org/7e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e3m RCSB], [https://www.ebi.ac.uk/pdbsum/7e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e3m ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: Huang J]] | |||
[[Category: Liu ZH]] | |||
[[Category: Lu WQ]] | |||
[[Category: Tang Y]] | |||
[[Category: Wu ZR]] | |||
Latest revision as of 19:45, 29 November 2023
RORgamma LBD complexed with Panaxatriol and SRC2.2RORgamma LBD complexed with Panaxatriol and SRC2.2
Structural highlights
FunctionRORG_HUMAN Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. |
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