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==== | ==Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation== | ||
<StructureSection load='7dci' size='340' side='right'caption='[[7dci]]' scene=''> | <StructureSection load='7dci' size='340' side='right'caption='[[7dci]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7dci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DCI FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dci OCA], [https://pdbe.org/7dci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dci RCSB], [https://www.ebi.ac.uk/pdbsum/7dci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dci ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dci OCA], [https://pdbe.org/7dci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dci RCSB], [https://www.ebi.ac.uk/pdbsum/7dci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dci ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HSF2_HUMAN HSF2_HUMAN] DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | |||
==See Also== | |||
*[[Heat shock factor|Heat shock factor]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Wei L]] | ||
Latest revision as of 19:30, 29 November 2023
Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientationCrystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation
Structural highlights
FunctionHSF2_HUMAN DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. See Also |
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