7cj2: Difference between revisions
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==== | ==Crystal structure of the Fab antibody complexed with human YKL-40== | ||
<StructureSection load='7cj2' size='340' side='right'caption='[[7cj2]]' scene=''> | <StructureSection load='7cj2' size='340' side='right'caption='[[7cj2]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7cj2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJ2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cj2 OCA], [https://pdbe.org/7cj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cj2 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cj2 OCA], [https://pdbe.org/7cj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cj2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Choi S]] | ||
[[Category: Hong JT]] | |||
[[Category: Kim DY]] | |||
[[Category: Lee SJ]] | |||
[[Category: Lee WK]] | |||
[[Category: Na JH]] | |||
[[Category: Woo JR]] | |||