7c37: Difference between revisions
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== | ==Crystal structure of AofleA from Arthrobotrys oligospora== | ||
<StructureSection load='7c37' size='340' side='right'caption='[[7c37]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='7c37' size='340' side='right'caption='[[7c37]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7c37]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[7c37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orbilia_oligospora_ATCC_24927 Orbilia oligospora ATCC 24927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C37 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.451Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCN:BICINE'>BCN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c37 OCA], [https://pdbe.org/7c37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c37 RCSB], [https://www.ebi.ac.uk/pdbsum/7c37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c37 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G1XA82_ARTOA G1XA82_ARTOA] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Orbilia oligospora ATCC 24927]] | ||
[[Category: Liu | [[Category: Cheng X]] | ||
[[Category: Wang | [[Category: Liu M]] | ||
[[Category: Wang | [[Category: Wang J]] | ||
[[Category: Zhang | [[Category: Wang M]] | ||
[[Category: Zhang M]] | |||
Latest revision as of 18:53, 29 November 2023
Crystal structure of AofleA from Arthrobotrys oligosporaCrystal structure of AofleA from Arthrobotrys oligospora
Structural highlights
FunctionPublication Abstract from PubMedFungal lectin can bind specific carbohydrate structures of the host and work in recognition and adhesion or as a toxic factor. AofleA, as a fucose-specific lectin from widely studied nematode predatory fungus Arthrobotrys oligospora, possibly plays a key role in the event of capturing nematodes, but the mechanism remains unknown. Here we report the crystal structure of AofleA, which exists as a homodimer with each subunit folds as a six-bladed beta-propeller. Our structural and biological results revealed that three of the six putative binding sites of AofleA had fucose-binding abilities. In addition, we found that AofleA could bind to the pharynx and intestine of the nematode in a fucose-binding-dependent manner. Our results facilitate the understanding of the mechanism that fucose-specific lectin mediates fungi-nematodes interaction, and provide structural information for the development of potential applications of AofleA. Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora.,Liu M, Cheng X, Wang J, Tian D, Tang K, Xu T, Zhang M, Wang Y, Wang M Int J Biol Macromol. 2020 Jul 19;164:783-793. doi:, 10.1016/j.ijbiomac.2020.07.173. PMID:32698064[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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