6lxu: Difference between revisions
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==Crystal structure of methionine gamma-lyase from Fusobacterium nucleatum== | ==Crystal structure of methionine gamma-lyase from Fusobacterium nucleatum== | ||
<StructureSection load='6lxu' size='340' side='right'caption='[[6lxu]]' scene=''> | <StructureSection load='6lxu' size='340' side='right'caption='[[6lxu]], [[Resolution|resolution]] 1.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXU FirstGlance]. <br> | <table><tr><td colspan='2'>[[6lxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._nucleatum_ATCC_25586 Fusobacterium nucleatum subsp. nucleatum ATCC 25586]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxu OCA], [https://pdbe.org/6lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxu RCSB], [https://www.ebi.ac.uk/pdbsum/6lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxu ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxu OCA], [https://pdbe.org/6lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxu RCSB], [https://www.ebi.ac.uk/pdbsum/6lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxu ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MEGL_FUSNN MEGL_FUSNN] Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia, and that of L-homocysteine (By similarity). Can also use L-cysteine as substrate, catalyzing its alpha,beta-elimination; this activity seems to only minimally contribute to the production of hydrogen sulfide (H2S) by F.nucleatum in the oral cavity, which is toxic for a large variety of cells in periodontal regions (PubMed:21798982).[UniProtKB:Q8L0X4]<ref>PMID:21798982</ref> | |||
==See Also== | |||
*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Fusobacterium nucleatum subsp. nucleatum ATCC 25586]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kezuka Y]] | [[Category: Kezuka Y]] | ||
[[Category: Nonaka T]] | [[Category: Nonaka T]] | ||
[[Category: Yoshida Y]] | [[Category: Yoshida Y]] | ||