5nrf: Difference between revisions
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==Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7i== | ==Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7i== | ||
<StructureSection load='5nrf' size='340' side='right' caption='[[5nrf]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='5nrf' size='340' side='right'caption='[[5nrf]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5nrf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NRF OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5nrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NRF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=95Q:1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-chlorophenyl)ethyl]-~{N}-(phenylmethyl)piperidin-4-amine'>95Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.447Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=95Q:1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-chlorophenyl)ethyl]-~{N}-(phenylmethyl)piperidin-4-amine'>95Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nrf OCA], [https://pdbe.org/5nrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nrf RCSB], [https://www.ebi.ac.uk/pdbsum/5nrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nrf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5nrf" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5nrf" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Chitinase 3D structures|Chitinase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Beckett | [[Category: Large Structures]] | ||
[[Category: Conway | [[Category: Beckett P]] | ||
[[Category: Cousido-Siah | [[Category: Conway B]] | ||
[[Category: Czestkowski | [[Category: Cousido-Siah A]] | ||
[[Category: Dymek | [[Category: Czestkowski W]] | ||
[[Category: Dzwonek | [[Category: Dymek B]] | ||
[[Category: Fadel | [[Category: Dzwonek K]] | ||
[[Category: Golab | [[Category: Fadel F]] | ||
[[Category: Golebiowski | [[Category: Golab J]] | ||
[[Category: Hungerford | [[Category: Golebiowski A]] | ||
[[Category: Jedrzejczak | [[Category: Hungerford WM]] | ||
[[Category: Koralewski | [[Category: Jedrzejczak A]] | ||
[[Category: Mahboubi | [[Category: Koralewski R]] | ||
[[Category: Mazur | [[Category: Mahboubi K]] | ||
[[Category: Mitschler | [[Category: Mazur M]] | ||
[[Category: Noonan | [[Category: Mitschler A]] | ||
[[Category: Olczak | [[Category: Noonan T]] | ||
[[Category: Olejniczak | [[Category: Olczak J]] | ||
[[Category: Podjarny | [[Category: Olejniczak S]] | ||
[[Category: Sheeler | [[Category: Podjarny A]] | ||
[[Category: Sklepkiewicz | [[Category: Sheeler R]] | ||
[[Category: Zagozdzon | [[Category: Sklepkiewicz P]] | ||
[[Category: Zagozdzon A]] | |||