2mfx: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1== | ==Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1== | ||
<StructureSection load='2mfx' size='340' side='right'caption='[[2mfx | <StructureSection load='2mfx' size='340' side='right'caption='[[2mfx]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mfx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MFX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mfx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MFX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfx OCA], [https://pdbe.org/2mfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mfx RCSB], [https://www.ebi.ac.uk/pdbsum/2mfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mfx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mfx OCA], [https://pdbe.org/2mfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mfx RCSB], [https://www.ebi.ac.uk/pdbsum/2mfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mfx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CA1A_CONVC CA1A_CONVC] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC(50)=7.2 uM), alpha-3/beta-2 (IC(50)=7.3 uM), alpha-3/beta-4 (IC(50)=4.2 uM), alpha-3 or -5/beta-4 (IC(50)<30 uM), alpha-4/beta-2 (IC(50)<30 uM), alpha-4/beta-4 (IC(50)<30 uM) and alpha/beta/gamma/delta (IC(50)<30 uM) subunits.<ref>PMID:12779345</ref> <ref>PMID:15770155</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Conus victoriae]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Macraild CA]] | |||
[[Category: Macraild | [[Category: Norton RS]] | ||
[[Category: Norton | [[Category: Robinson AJ]] | ||
[[Category: Robinson | [[Category: Robinson SD]] | ||
[[Category: Robinson | [[Category: Van Lierop BJ]] | ||
[[Category: | |||