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New page: left|200px<br /><applet load="1c34" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c34" /> '''SOLUTION STRUCTURE OF A QUADRUPLEX FORMING D... |
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== | ==SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE== | ||
Potassium can stabilize the formation of chair- or edge-type quadruplex | <StructureSection load='1c34' size='340' side='right'caption='[[1c34]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1c34]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C34 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c34 OCA], [https://pdbe.org/1c34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c34 RCSB], [https://www.ebi.ac.uk/pdbsum/1c34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c34 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Potassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat and other DNAs, information about the details of the potassium-quadruplex DNA interactions are of interest. The structures of the 1:1 and the fully saturated, 2:1, potassium-DNA complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination of experimental NMR results and restrained molecular dynamics simulations. The refined structures have been used to model the interactions at the potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA structures indicates how potassium binding can determine the folding pattern of the DNA. In each binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and the guanine residues of the adjacent quartet. | |||
Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA.,Marathias VM, Bolton PH Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199<ref>PMID:10756199</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1c34" style="background-color:#fffaf0;"></div> | ||
[[Category: Bolton | == References == | ||
[[Category: Marathias | <references/> | ||
[[Category: Wang | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bolton PH]] | |||
[[Category: Marathias VM]] | |||
[[Category: Wang K]] | |||
Latest revision as of 14:38, 22 November 2023
SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATESOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE
Structural highlights
Publication Abstract from PubMedPotassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat and other DNAs, information about the details of the potassium-quadruplex DNA interactions are of interest. The structures of the 1:1 and the fully saturated, 2:1, potassium-DNA complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination of experimental NMR results and restrained molecular dynamics simulations. The refined structures have been used to model the interactions at the potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA structures indicates how potassium binding can determine the folding pattern of the DNA. In each binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and the guanine residues of the adjacent quartet. Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA.,Marathias VM, Bolton PH Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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