7q2j: Difference between revisions

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-====
+==Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer==
-<StructureSection load='7q2j' size='340' side='right'caption='[[7q2j]]' scene=''>
+<StructureSection load='7q2j' size='340' side='right'caption='[[7q2j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7q2j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q2J FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q2j OCA], [https://pdbe.org/7q2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q2j RCSB], [https://www.ebi.ac.uk/pdbsum/7q2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q2j ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8KH:N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide'>8KH</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q2j OCA], [https://pdbe.org/7q2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q2j RCSB], [https://www.ebi.ac.uk/pdbsum/7q2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q2j ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>   The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
+==See Also==
+*[[Elongation factor 3D structures|Elongation factor 3D structures]]
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Adhikari B]]
+[[Category: Doelle A]]
+[[Category: Knapp S]]
+[[Category: Kraemer A]]
+[[Category: Schwalm MP]]
+[[Category: Wolf E]]