6le9: Difference between revisions

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<StructureSection load='6le9' size='340' side='right'caption='[[6le9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6le9' size='340' side='right'caption='[[6le9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6le9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LE9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LE9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6le9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LE9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6le9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6le9 OCA], [http://pdbe.org/6le9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6le9 RCSB], [http://www.ebi.ac.uk/pdbsum/6le9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6le9 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6le9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6le9 OCA], [https://pdbe.org/6le9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6le9 RCSB], [https://www.ebi.ac.uk/pdbsum/6le9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6le9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2B1K_HUMAN H2B1K_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Telomeres protect the ends of our chromosomes and are key to maintaining genomic integrity during cell division and differentiation. However, our knowledge of telomeric chromatin and nucleosome structure at the molecular level is limited. Here, we aimed to define the structure, dynamics as well as properties in solution of the human telomeric nucleosome. We first determined the 2.2 A crystal structure of a human telomeric nucleosome core particle (NCP) containing 145 bp DNA, which revealed the same helical path for the DNA as well as symmetric stretching in both halves of the NCP as that of the 145 bp '601' NCP. In solution, the telomeric nucleosome exhibited a less stable and a markedly more dynamic structure compared to NCPs containing DNA positioning sequences. These observations provide molecular insights into how telomeric DNA forms nucleosomes and chromatin and advance our understanding of the unique biological role of telomeres.


The human telomeric nucleosome displays distinct structural and dynamic properties.,Soman A, Liew CW, Teo HL, Berezhnoy NV, Olieric V, Korolev N, Rhodes D, Nordenskiold L Nucleic Acids Res. 2020 Jun 4;48(10):5383-5396. doi: 10.1093/nar/gkaa289. PMID:32374876<ref>PMID:32374876</ref>
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6le9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berezhnoy, N]]
[[Category: Berezhnoy N]]
[[Category: Korolev, N]]
[[Category: Korolev N]]
[[Category: Liew, C W]]
[[Category: Liew CW]]
[[Category: Nordenskiold, L]]
[[Category: Nordenskiold L]]
[[Category: Rhodes, D]]
[[Category: Rhodes D]]
[[Category: Soman, A]]
[[Category: Soman A]]
[[Category: Teo, H L]]
[[Category: Teo HL]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein-dna complex]]
[[Category: Nucleosome core particle]]
[[Category: Telomeric dna]]

Latest revision as of 13:58, 22 November 2023

The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic PropertiesThe Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties

Structural highlights

6le9 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H31_HUMAN

See Also

6le9, resolution 2.60Å

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