6kh5: Difference between revisions
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==Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes== | |||
<StructureSection load='6kh5' size='340' side='right'caption='[[6kh5]], [[Resolution|resolution]] 2.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6kh5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_japonicus Penaeus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KH5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.294Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kh5 OCA], [https://pdbe.org/6kh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kh5 RCSB], [https://www.ebi.ac.uk/pdbsum/6kh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kh5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/T2B7E1_PENJP T2B7E1_PENJP] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Metal-organic frameworks (MOFs) hold great promise for numerous applications. However, proteins, carriers of biological functions in living systems, have not yet been fully explored as building blocks for the construction of MOFs. Here, we presented a strategy for the fabrication of binary MOFs. Considering octahedral ferritin symmetry, we firstly incorporated four His 2 (His-His) motifs into the exterior surface of ferritin nanocage nearby each C 4 channel, yielding protein linkers with multiple metal binding sites (bisH-SF). Secondly, by adding nickel ions to bisH-SF solutions to triggers the self-assembly of ferritin nanocages into a porous 3D crystalline MOF with designed protein lattice, where two adjacent ferritin molecules along the C 4 symmetry axes are bridged by four dinuclear or tetranuclear nickel clusters depending on Ni 2+ concentration. This work provides a simple approach for precise control over a binary protein-metal crystalline framework, and resulting MOFs exhibited inherent ferroxidase activity and peroxidase-like catalytic activity. | |||
Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.,Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500<ref>PMID:31820500</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6kh5" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Ferritin 3D structures|Ferritin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Penaeus japonicus]] | |||
[[Category: Chen H]] | |||
[[Category: Gu C]] | |||
[[Category: Wang H]] | |||
[[Category: Wang Y]] | |||
[[Category: Zhang T]] | |||
[[Category: Zhao G]] | |||
Latest revision as of 13:33, 22 November 2023
Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodesDesign and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes
Structural highlights
FunctionT2B7E1_PENJP Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] Publication Abstract from PubMedMetal-organic frameworks (MOFs) hold great promise for numerous applications. However, proteins, carriers of biological functions in living systems, have not yet been fully explored as building blocks for the construction of MOFs. Here, we presented a strategy for the fabrication of binary MOFs. Considering octahedral ferritin symmetry, we firstly incorporated four His 2 (His-His) motifs into the exterior surface of ferritin nanocage nearby each C 4 channel, yielding protein linkers with multiple metal binding sites (bisH-SF). Secondly, by adding nickel ions to bisH-SF solutions to triggers the self-assembly of ferritin nanocages into a porous 3D crystalline MOF with designed protein lattice, where two adjacent ferritin molecules along the C 4 symmetry axes are bridged by four dinuclear or tetranuclear nickel clusters depending on Ni 2+ concentration. This work provides a simple approach for precise control over a binary protein-metal crystalline framework, and resulting MOFs exhibited inherent ferroxidase activity and peroxidase-like catalytic activity. Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.,Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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