6ke2: Difference between revisions
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==ABloop reengineered Ferritin Nanocage== | |||
<StructureSection load='6ke2' size='340' side='right'caption='[[6ke2]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ke2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KE2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.798Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ke2 OCA], [https://pdbe.org/6ke2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ke2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ke2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ke2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH </= 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage. | |||
AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.,Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j. PMID:31556881<ref>PMID:31556881</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Wang | <div class="pdbe-citations 6ke2" style="background-color:#fffaf0;"></div> | ||
[[Category: Wang | |||
==See Also== | |||
*[[Ferritin 3D structures|Ferritin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Wang HF]] | |||
[[Category: Wang WM]] | |||
Latest revision as of 13:31, 22 November 2023
ABloop reengineered Ferritin NanocageABloop reengineered Ferritin Nanocage
Structural highlights
FunctionFRIH_HUMAN Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Publication Abstract from PubMedHuman ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH </= 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.,Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j. PMID:31556881[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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