6k0x: Difference between revisions

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-'''Unreleased structure'''
-The entry 6k0x is ON HOLD
+==Structure of N6AMT1-TRMT112 Complex with SAM==
+<StructureSection load='6k0x' size='340' side='right'caption='[[6k0x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6k0x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K0X FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k0x OCA], [https://pdbe.org/6k0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k0x RCSB], [https://www.ebi.ac.uk/pdbsum/6k0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k0x ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/N6MT1_HUMAN N6MT1_HUMAN] Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).[UniProtKB:Q6SKR2]<ref>PMID:18539146</ref> <ref>PMID:20606008</ref> <ref>PMID:21193388</ref> <ref>PMID:25997655</ref> <ref>PMID:30017583</ref>
-Authors: Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
+==See Also==
+*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
-Description: Structure of N6AMT1-TRMT112 Complex with SAM
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Guo, Q]]
+__TOC__
-[[Category: Xu, C]]
+</StructureSection>
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Homo sapiens]]
-[[Category: Liao, S]]
+[[Category: Large Structures]]
+[[Category: Guo Q]]
+[[Category: Liao S]]
+[[Category: Xu C]]