6j57: Difference between revisions

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-'''Unreleased structure'''
-The entry 6j57 is ON HOLD  until Paper Publication
+==Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum==
+<StructureSection load='6j57' size='340' side='right'caption='[[6j57]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6j57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J57 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j57 OCA], [https://pdbe.org/6j57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j57 RCSB], [https://www.ebi.ac.uk/pdbsum/6j57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j57 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8NLC0_CORGL Q8NLC0_CORGL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Fumarylacetoacetate hydrolase (FAH) superfamily proteins are found ubiquitously in microbial pathways involved in the catabolism of aromatic substances. Although extensive bioinformatic data on these proteins have been acquired, confusion caused by problems with the annotation of these proteins hinders research into determining their physiological functions. Here we classify 606 FAH superfamily proteins using a maximum likelihood (ML) phylogenetic tree, comparative gene-neighbourhood patterns and in vitro enzyme assays. The FAH superfamily proteins used for the analyses are divided into five distinct subfamilies, and two of them, FPH-A and FPH-B, contain the majority of the proteins of undefined function. These subfamilies include clusters designated FPH-I and FPH-II, respectively, which include two distinct types of fumarylpyruvate hydrolase (FPH), an enzyme involved in the final step of the gentisate pathway. We determined the crystal structures of these FPH enzymes at 2.0 A resolutions and investigate the substrate binding mode by which these types of enzymes can accommodate fumarylpyruvate as a substrate. Consequentially, we identify the molecular signatures of the two types of FPH enzymes among the broadly conserved FAH superfamily proteins. Our studies allowed us to predict the relationship of unknown FAH superfamily proteins using their sequence information.
-Authors: Hong, H., Seo, H., Kim, K.-J., Park, W.
+Sequence, structure and function-based classification of the broadly conserved FAH superfamily reveals two distinct fumarylpyruvate hydrolase subfamilies.,Hong H, Seo H, Park W, Kim KJ Environ Microbiol. 2019 Oct 27. doi: 10.1111/1462-2920.14844. PMID:31657110<ref>PMID:31657110</ref>
-Description: Crystal structure of fumarylpyruvate hydrolase from Corynebacterium glutamicum
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Park, W]]
+<div class="pdbe-citations 6j57" style="background-color:#fffaf0;"></div>
-[[Category: Kim, K.-J]]
+== References ==
-[[Category: Seo, H]]
+<references/>
-[[Category: Hong, H]]
+__TOC__
+</StructureSection>
+[[Category: Corynebacterium glutamicum]]
+[[Category: Large Structures]]
+[[Category: Hong H]]
+[[Category: Kim K-J]]
+[[Category: Park W]]
+[[Category: Seo H]]