6iqc: Difference between revisions
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The | ==Wild-type Programmed Cell Death 5 protein from Sulfolobus solfataricus== | ||
<StructureSection load='6iqc' size='340' side='right'caption='[[6iqc]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6iqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IQC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iqc OCA], [https://pdbe.org/6iqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iqc RCSB], [https://www.ebi.ac.uk/pdbsum/6iqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iqc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Y352_SACS2 Y352_SACS2] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Programmed cell death 5 (PDCD5) is a vital signaling protein in the apoptosis pathway in eukaryotes. It is known that there are two dissociated N-terminal regions and a triple-helix core in eukaryotic PDCD5. Structural and functional studies of PDCD5 from hyperthermophilic archaea have been limited to date. Here, the PDCD5 homolog Sso0352 (SsoPDCD5) was identified in Sulfolobus solfataricus, the SsoPDCD5 protein was expressed and crystallized, and the phase was identified by single-wavelength anomalous diffraction. The native SsoPDCD5 crystal belonged to space group C2 and diffracted to 1.49 A resolution. This is the first crystal structure of a PDCD5 homolog to be solved. SsoPDCD5 shares a similar triple-helix bundle with eukaryotic PDCD5 but has a long alpha-helix in the N-terminus. A structural search and biochemical data suggest that SsoPDCD5 may function as a DNA-binding protein. | |||
Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus.,Lin KF, Hsu JY, Hsieh DL, Tsai MJ, Yeh CH, Chen CY Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):73-79. doi:, 10.1107/S2053230X18017673. Epub 2019 Jan 23. PMID:30713157<ref>PMID:30713157</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6iqc" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharolobus solfataricus P2]] | |||
[[Category: Chen CY]] | |||
[[Category: Hsu CY]] | |||
[[Category: Lin KF]] | |||
[[Category: Tsai MJ]] | |||
Latest revision as of 12:49, 22 November 2023
Wild-type Programmed Cell Death 5 protein from Sulfolobus solfataricusWild-type Programmed Cell Death 5 protein from Sulfolobus solfataricus
Structural highlights
FunctionPublication Abstract from PubMedProgrammed cell death 5 (PDCD5) is a vital signaling protein in the apoptosis pathway in eukaryotes. It is known that there are two dissociated N-terminal regions and a triple-helix core in eukaryotic PDCD5. Structural and functional studies of PDCD5 from hyperthermophilic archaea have been limited to date. Here, the PDCD5 homolog Sso0352 (SsoPDCD5) was identified in Sulfolobus solfataricus, the SsoPDCD5 protein was expressed and crystallized, and the phase was identified by single-wavelength anomalous diffraction. The native SsoPDCD5 crystal belonged to space group C2 and diffracted to 1.49 A resolution. This is the first crystal structure of a PDCD5 homolog to be solved. SsoPDCD5 shares a similar triple-helix bundle with eukaryotic PDCD5 but has a long alpha-helix in the N-terminus. A structural search and biochemical data suggest that SsoPDCD5 may function as a DNA-binding protein. Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus.,Lin KF, Hsu JY, Hsieh DL, Tsai MJ, Yeh CH, Chen CY Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):73-79. doi:, 10.1107/S2053230X18017673. Epub 2019 Jan 23. PMID:30713157[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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