6ipp: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6ipp is ON HOLD
+==Non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C==
+<StructureSection load='6ipp' size='340' side='right'caption='[[6ipp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ipp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IPP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.699&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ipp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipp OCA], [https://pdbe.org/6ipp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ipp RCSB], [https://www.ebi.ac.uk/pdbsum/6ipp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Constructing different protein nanostructures with high-order discrete architectures by using one single building block remains a challenge. Here, we present a simple, effective disulfide-mediated approach to prepare a set of protein nanocages with different geometries from single building block. By genetically deleting an inherent intra-subunit disulfide bond, we can render the conversion of an 8-mer bowl-like protein architecture (NF-8) into a 24-mer ferritin-like nanocage in solution, while selective insertion of an inter-subunit disulfide bond into NF-8 triggers its conversion into a 16-mer lenticular nanocage. Deletion of the same intra-subunit disulfide bond and insertion of the inter-subunit disulfide bond results in the conversion of NF-8 into a 48-mer protein nanocage in solution. Thus, in the laboratory, simple mutation of one protein building block can generate three different protein nanocages in a manner that is highly reminiscent of natural pentamer building block originating from viral capsids that self-assemble into protein assemblies with different symmetries.
-Authors: Zang, J., Chen, H., Zhou, K., Zhao, G.
+Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.,Zang J, Chen H, Zhang X, Zhang C, Guo J, Du M, Zhao G Nat Commun. 2019 Feb 15;10(1):778. doi: 10.1038/s41467-019-08788-9. PMID:30770832<ref>PMID:30770832</ref>
-Description: non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Zhou, K]]
+<div class="pdbe-citations 6ipp" style="background-color:#fffaf0;"></div>
-[[Category: Zang, J]]
-[[Category: Chen, H]]
+==See Also==
-[[Category: Zhao, G]]
+*[[Ferritin 3D structures|Ferritin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen H]]
+[[Category: Zang J]]
+[[Category: Zhao G]]
+[[Category: Zhou K]]