6id4: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6id4 is ON HOLD
+==Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01==
+<StructureSection load='6id4' size='340' side='right'caption='[[6id4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6id4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ID4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ID4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6id4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6id4 OCA], [https://pdbe.org/6id4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6id4 RCSB], [https://www.ebi.ac.uk/pdbsum/6id4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6id4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/F6IQY1_HUMAN F6IQY1_HUMAN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2.4 A resolution map of the binding interface of this antibody on HLA-A*11:01 and compare the structural determinants with those utilized by T-cell receptor (TCR), killer-cell immunoglobulin-like receptor (KIR) and CD8 on the same molecule. These data provide a mechanistic insight into the paratope-epitope relationship between an alloantibody and its target HLA molecule in a biological context where other immune receptors are concomitantly engaged. This has important implications for our interpretation of serologic binding patterns of anti-HLA antibodies in sensitized individuals and thus, for the biology of human alloresponses.
-Authors: Lescar, J., Wong, Y.H., Liew, C.W., Gu, Y., MacAry, P.A.
+Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.,Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1. PMID:30792391<ref>PMID:30792391</ref>
-Description: Complex of HLA-A*11:01 binding to alloantibody 2E3
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Macary, P.A]]
+<div class="pdbe-citations 6id4" style="background-color:#fffaf0;"></div>
-[[Category: Gu, Y]]
-[[Category: Liew, C.W]]
+==See Also==
-[[Category: Lescar, J]]
+*[[Antibody 3D structures|Antibody 3D structures]]
-[[Category: Wong, Y.H]]
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
+*[[MHC 3D structures|MHC 3D structures]]
+*[[MHC I 3D structures|MHC I 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Human immunodeficiency virus 1]]
+[[Category: Large Structures]]
+[[Category: Gu Y]]
+[[Category: Lescar J]]
+[[Category: Liew CW]]
+[[Category: MacAry PA]]
+[[Category: Wong YH]]