6aax: Difference between revisions
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<StructureSection load='6aax' size='340' side='right'caption='[[6aax]], [[Resolution|resolution]] 2.99Å' scene=''> | <StructureSection load='6aax' size='340' side='right'caption='[[6aax]], [[Resolution|resolution]] 2.99Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6aax]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6aax]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AAX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.994Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aax OCA], [https://pdbe.org/6aax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aax RCSB], [https://www.ebi.ac.uk/pdbsum/6aax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aax ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.<ref>PMID:11809803</ref> <ref>PMID:12068295</ref> <ref>PMID:12897151</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6aax" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6aax" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Adenosine dimethyltransferase 3D structures|Adenosine dimethyltransferase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gong | [[Category: Gong Q]] | ||
[[Category: Li | [[Category: Li F]] | ||
[[Category: Liu | [[Category: Liu X]] | ||
[[Category: Shen | [[Category: Shen S]] | ||
[[Category: Shi | [[Category: Shi Y]] | ||
[[Category: Wu | [[Category: Wu J]] | ||
[[Category: Wu | [[Category: Wu P]] | ||
[[Category: Zhang | [[Category: Zhang H]] | ||