6a28: Difference between revisions

<StructureSection load='6a28' size='340' side='right'caption='[[6a28]], [[Resolution|resolution]] 2.19&Aring;' scene=''>

<table><tr><td colspan='2'>[[6a28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A28 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.193&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a28 OCA], [https://pdbe.org/6a28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a28 RCSB], [https://www.ebi.ac.uk/pdbsum/6a28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a28 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>  

[[Category: Adachi M]]

[[Category: Arai S]]

[[Category: Kuroki R]]

[[Category: Narumi I]]

[[Category: Satoh K]]

[[Category: Shibazaki C]]

[[Category: Shimizu R]]