5z0a: Difference between revisions
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==ST0452(Y97N)-GlcNAc binding form== | ==ST0452(Y97N)-GlcNAc binding form== | ||
<StructureSection load='5z0a' size='340' side='right' caption='[[5z0a]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='5z0a' size='340' side='right'caption='[[5z0a]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5z0a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z0A OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5z0a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z0A FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z0a OCA], [https://pdbe.org/5z0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z0a RCSB], [https://www.ebi.ac.uk/pdbsum/5z0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z0a ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/S1PNA_SULTO S1PNA_SULTO] Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).<ref>PMID:15598657</ref> <ref>PMID:20400541</ref> <ref>PMID:25567746</ref> <ref>PMID:27864169</ref> <ref>PMID:30291121</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sulfurisphaera tokodaii str. 7]] | ||
[[Category: | [[Category: Dadashipour M]] | ||
[[Category: | [[Category: Honda Y]] | ||
[[Category: | [[Category: Ito S]] | ||
[[Category: | [[Category: Kawarabayasi Y]] | ||
[[Category: | [[Category: Nakano S]] | ||
[[Category: | [[Category: Zhang Z]] | ||