5yu6: Difference between revisions

<table><tr><td colspan='2'>[[5yu6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YU6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.997&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yu6 OCA], [https://pdbe.org/5yu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yu6 RCSB], [https://www.ebi.ac.uk/pdbsum/5yu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yu6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/XPO5_HUMAN XPO5_HUMAN] Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.<ref>PMID:12426392</ref> <ref>PMID:11777942</ref> <ref>PMID:12426393</ref> <ref>PMID:14681208</ref> <ref>PMID:12509441</ref> <ref>PMID:14570900</ref> <ref>PMID:15254228</ref> <ref>PMID:14730017</ref> <ref>PMID:14631048</ref> <ref>PMID:15613540</ref> <ref>PMID:19124606</ref>  Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference, and adenovirus VA1 dsRNA. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.<ref>PMID:12426392</ref> <ref>PMID:11777942</ref> <ref>PMID:12426393</ref> <ref>PMID:14681208</ref> <ref>PMID:12509441</ref> <ref>PMID:14570900</ref> <ref>PMID:15254228</ref> <ref>PMID:14730017</ref> <ref>PMID:14631048</ref> <ref>PMID:15613540</ref> <ref>PMID:19124606</ref>  

[[Category: Canis lupus familiaris]]

[[Category: Homo sapiens]]

[[Category: Unidentified]]

[[Category: Jiko C]]

[[Category: Lee SJ]]

[[Category: Yamashita E]]

[[Category: Yamazawa R]]