5ysw: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ysw is ON HOLD  until Paper Publication
+==Crystal Structure Analysis of Rif16 in complex with R-L==
+<StructureSection load='5ysw' size='340' side='right'caption='[[5ysw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ysw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_mediterranei_U32 Amycolatopsis mediterranei U32]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YSW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9LF:(2S,12E,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-9-yl+hydroxyacetate'>9LF</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ysw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysw OCA], [https://pdbe.org/5ysw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ysw RCSB], [https://www.ebi.ac.uk/pdbsum/5ysw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0H3CVZ6_AMYMU A0A0H3CVZ6_AMYMU]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families.
-Authors: Li, F.W., Qi, F.F., Xiao, Y.L., Zhao, G.P., Li, S.Y.
+Deciphering the late steps of rifamycin biosynthesis.,Qi F, Lei C, Li F, Zhang X, Wang J, Zhang W, Fan Z, Li W, Tang GL, Xiao Y, Zhao G, Li S Nat Commun. 2018 Jun 14;9(1):2342. doi: 10.1038/s41467-018-04772-x. PMID:29904078<ref>PMID:29904078</ref>
-Description: Crystal Structure Analysis of Rif16 in complex with R-L
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Zhao, G.P]]
+<div class="pdbe-citations 5ysw" style="background-color:#fffaf0;"></div>
-[[Category: Li, S.Y]]
-[[Category: Qi, F.F]]
+==See Also==
-[[Category: Xiao, Y.L]]
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
-[[Category: Li, F.W]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Amycolatopsis mediterranei U32]]
+[[Category: Large Structures]]
+[[Category: Li FW]]
+[[Category: Li SY]]
+[[Category: Qi FF]]
+[[Category: Xiao YL]]
+[[Category: Zhao GP]]