5xa0: Difference between revisions

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<StructureSection load='5xa0' size='340' side='right'caption='[[5xa0]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
<StructureSection load='5xa0' size='340' side='right'caption='[[5xa0]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xa0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XA0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XA0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xa0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XA0 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x9z|5x9z]], [[5xa1|5xa1]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.812&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Itpr1, Insp3r, Pcd6, Pcp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xa0 OCA], [https://pdbe.org/5xa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xa0 RCSB], [https://www.ebi.ac.uk/pdbsum/5xa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xa0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xa0 OCA], [http://pdbe.org/5xa0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xa0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xa0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xa0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Hamada, K]]
[[Category: Hamada K]]
[[Category: Mikoshiba, K]]
[[Category: Mikoshiba K]]
[[Category: Miyatake, H]]
[[Category: Miyatake H]]
[[Category: Terauchi, A]]
[[Category: Terauchi A]]
[[Category: Metal transport]]
[[Category: Receptor channel calcium]]

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