Sodium-calcium exchanger: Difference between revisions
New page: == Introduction == <Structure load='3V5S' size='350' frame='true' align='right' caption='Structure of NCX_Mj exchanger from ''Methanocaldococcus jannaschii''' scene='Insert optional scene ... |
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== Introduction == | == Introduction == | ||
<Structure load='3V5S' size='350' frame='true' align='right' caption='Structure of NCX_Mj exchanger from | <Structure load='3V5S' size='350' frame='true' align='right' caption='Structure of NCX_Mj exchanger from Methanocaldococcus jannaschii complex with Cd++ (PDB code [[3v5s]])' scene='' /> | ||
''Methanococcus janaschii'' sodium calcium exchanger (NCX_Mj) is a member of the NCX (sodium/calcium exchanger) family of proteins, expressed in the archaebacteria ''Methanococcus jannaschii''. NCX_Mj is a membrane protein capable of transporting calcium ions across the plasma membrane (PM) by utilizing the electrochemical gradient of sodium ions. In physiological conditions, it's function is most probably related to calcium homeostasis in the cell. NCX_Mj is to date, the only member of the NCX protein family which it's structure had been resolved, and only in the outward facing (OF) conformation. | ''Methanococcus janaschii'' '''sodium calcium exchanger''' (NCX_Mj) is a member of the NCX (sodium/calcium exchanger) family of proteins, expressed in the archaebacteria ''Methanococcus jannaschii''. NCX_Mj is a membrane protein capable of transporting calcium ions across the plasma membrane (PM) by utilizing the electrochemical gradient of sodium ions. In physiological conditions, it's function is most probably related to calcium homeostasis in the cell. NCX_Mj is to date, the only member of the NCX protein family which it's structure had been resolved, and only in the outward facing (OF) conformation. | ||
== Calcium Cation Antiporter Superfamily: == | == Calcium Cation Antiporter Superfamily: == | ||
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== Regulation: == | == Regulation: == | ||
NCX is regulated by cytosolic Na<sup>+</sup> and Ca<sup>2+</sup> concentrations, pH, ATP and PIP<sub>2</sub>.<ref name=khananshvili13 /><ref name=khananshvili14 /> | NCX is regulated by cytosolic Na<sup>+</sup> and Ca<sup>2+</sup> concentrations, pH, ATP and PIP<sub>2</sub>.<ref name=khananshvili13 /><ref name=khananshvili14 /> | ||
==3D structures of sodium/calcium exchanger== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
Domains – THB 306-359; Ca-binding 1 (CBD1) 402-541; Ca-binding 2 (CBD2) 533-724 | |||
[[8sgj]] – hNCX 1 + antibody + Ca + Na – human – Cryo EM<br /> | |||
[[8sgt]] – hNCX 1 + antibody + Ca – Cryo EM<br /> | |||
[[6z3z]], [[6z3y]] – NCX 9 – horse – Cryo EM<br /> | |||
[[6bv7]] – dNCX 1 THB domain + Na – dog - NMR<br /> | |||
[[2dpk]] – dNCX 1 CBD1 + Ca + guanidine <br /> | |||
[[2fws]], [[2fwu]] – dNCX 1 CBD1 + Ca - NMR <br /> | |||
[[3gin]] – dNCX 1 CBD1 (mutant) <br /> | |||
[[2qvk]], [[2qvm]] – dNCX 1 CBD2 + Ca <br /> | |||
[[2kls]], [[2klt]] – dNCX 1 CBD2 - NMR <br /> | |||
[[3us9]] – dNCX 1 CBD1+2 (mutant) + Ca <br /> | |||
[[3e9t]] – NCX CBD1 + Ca – ''Drosophila melanogaster''<br /> | |||
[[3v5s]] – MjNCX + Cd – ''Methanocaldococcus jannaschii''<br /> | |||
[[5hya]] – MjNCX + Na + Ca<br /> | |||
[[3v5u]], [[5hxc]], [[5jdg]], [[5jdh]] – MjNCX (mutant) + Na + Ca<br /> | |||
[[5hxe]] – MjNCX + Na<br /> | |||
[[5hwx]], [[5hwy]] – MjNCX (mutant) + Na<br /> | |||
[[5hxh]], [[5hxr]], [[5jdf]] – MjNCX (mutant) + Ca<br /> | |||
[[5hxs]], [[5jdl]] – MjNCX (mutant) + Sr<br /> | |||
[[5jdm]], [[5jdn]], [[5jdq]] – MjNCX (mutant) + Na + Sr<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||