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| '''Signal recognition particle receptor''' (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the [[Signal recognition particle protein|signal recognition particle (SRP)]]. SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called '''FtsY'''. | | '''Signal recognition particle receptor''' (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the [[Signal recognition particle protein|signal recognition particle (SRP)]]. SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called '''FtsY'''. |
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| | See also [[Intracellular receptors]] |
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| *<scene name='48/485587/Cv/6'>GTP binding site</scene>. Water molecules are shown as red spheres. | | *<scene name='48/485587/Cv/6'>GTP binding site</scene>. Water molecules are shown as red spheres. |
| *<scene name='48/485587/Cv/7'>Mg coordination site</scene>. | | *<scene name='48/485587/Cv/7'>Mg coordination site</scene>. |
| </StructureSection>
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| ==3D structures of signal recognition particle receptor== | | ==3D structures of signal recognition particle receptor== |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[Signal recognition particle receptor 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Signal recognition particle receptor
| | </StructureSection> |
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| **[[2fh5]] - hSRPR α+β subunits + GTP – human<br />
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| **[[6y32]] - hSRPR α subunit + SRP54 + GNP <br />
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| **[[5l3q]] - hSRPR α subunit + SRP54 + AMP + GNP <br />
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| **[[2go5]] - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - Cryo EM<br />
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| **[[7obq]] - rSRPR α+b subunits + dSRP19 + dSRP54 + dSRP68 + dSRP72 + RNA – rabbit - Cryo EM<br />
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| **[[7nfx]] - rSRPR α+b subunits in human ribosome - Cryo EM<br />
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| **[[1nrj]] – ySRPR α+β subunits + GTP – yeast<br />
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| **[[2ged]] - ySRPR β subunit (mutant)<br />
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| *Signal recognition particle receptor FtsY; Domain NG 195-498
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| **[[3jaj]], [[3jan]] – FtsY in ribosome - rabbit - Cryo EM<br />
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| **[[5l3r]] – SRPR FtsY + SRP54 - ''Arabidopsis thaliana''<br />
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| **[[1zu5]], [[1zu4]] – SRPR FtsY NG domain – ''Mycoplasma mycoides''<br />
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| **[[1vma]] – SRPR FtsY – ''Thermotoga maritima''<br />
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| **[[6cy1]] – EaSRPR FtsY – ''Elizabethkingia anopheles''<br />
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| **[[6cy5]] – EaSRPR FtsY NG domain + GDP<br />
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| **[[2q9a]] – TaSRPR FtsY – ''Thermus aquaticus''<br />
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| **[[2q9c]], [[2q9b]] – TaSRPR FtsY NG domain + GMPPNP<br />
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| **[[2j7p]], [[1rj9]], [[1okk]] – TaSRPR FtsY NG domain + SRP <br />
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| **[[2cnw]] – TaSRPR FtsY NG domain + SRP + GDP<br />
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| **[[5niy]] – EcSRPR FtsY – ''Escherichia coli''<br />
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| **[[6fpk]], [[6fpr]] – EcSRPR FtsY N-terminal<br />
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| **[[2yhs]], [[2qy9]], [[1fts]], [[6cqp]], [[6cs8]], [[6n5i]], [[6n5j]], [[6n6n]], [[6n9b]], [[6nc1]], [[6nc4]] – EcSRPR FtsY NG domain<br />
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| **[[6fqd]] – EcSRPR FtsY NG domain + GDP<br />
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| **[[7o9h]] – EcSRPR FtsY NG domain + pppGpp<br />
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| **[[6c58]], [[6cvd]], [[6dlx]] – EcSRPR FtsY NG domain + antibiotic<br />
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| **[[2iyl]] – EcSRPR FtsY residues 20-303 + GDP<br />
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| **[[2xxa]] - EcSRPR FtsY NG domain + SRP residues 1-433 (mutant) + 4.5SRNA<br />
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| **[[3zn8]] - EcSRPR FtsY NG domain + SRP54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B<br />
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| **[[4c7o]] – EcFtsY + EcSRP + SRP RNA<br />
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| **[[2xkv]] – EcFtsY + EcSRP NG+M domains + 4.5S RNA<br />
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| **[[5aka]], [[5gad]], [[5nco]], [[5gaf]], [[5gag]], [[5gah]] – EcFtsY in ribosome - Cryo EM<br />
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| **[[5l3w]] – SRPR FtsY NG domain - ''Sulfolobus acidocaldarius''<br />
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| **[[5l3s]] – SRPR FtsY + SRP54 + GNP - ''Sulfolobus solfataricus''<br />
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| **[[3dm9]], [[3dmd]], [[3e70]] – SRPR + GDP – ''Pyrococcus furiosus''
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |