Signal recognition particle protein: Difference between revisions

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Michal Harel, Alexander Berchansky

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 <StructureSection load='1e8o' size='350' side='right' scene='' caption='Human SRP9 (grey and pink) +SRP14 (green and yellow) complex with 7S RNA, GDP and sulfate [[1e8o]]'>
 '''Signal recognition particle''' (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes.  In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome.  The binding allows for the coupling of the translation process to the translocation process.  The SRP targets the nascent protein to the ER by docking into the [[Signal recognition particle receptor|SRP receptor]]<ref>PMID:15718142</ref>.  The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14<ref>PMID:7542942</ref>, SRP19<ref>PMID:11682607</ref>, SRP54<ref>PMID:9511762</ref>, SRP68, SRP72<ref>PMID:8388879</ref> and 7S RNA.  The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.
-</StructureSection>
 ==3D structures of signal recognition particle==
+[[Signal recognition particle 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Signal recognition particle
-**[[6y2z]], [[6y31]] – hSRP54 NG domain 1-296 - human<br />
-**[[6y30]] – hSRP54 NG domain (mutant)<br />
-**[[1qb2]] – hSRP54 M domain 326-434<br />
-**[[4p3f]] – hSRP68 (mutant)<br />
-**[[5m72]], [[5wrv]] – hSRP68 + SRP72<br />
-**[[5wrw]] – hSRP72<br />
-**[[1914]] – mSRP9/SRP14 – mouse<br />
-**[[1wgw]] – mSRP54 N terminal – NMR<br />
-**[[2hug]] – AtSRP43 chromodomain 2 + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
-**[[1x32]] - AtSRP43 chromodomain 1 – NMR<br />
-**[[5e4x]] - AtSRP43 chromodomain 3<br />
-**[[3deo]] - AtSRP43 residues 85-267<br />
-**[[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
-**[[2w9j]] – SRP14 residues 1-91 – fission yeast<br />
-**[[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
-**[[2ng1]] - TaSRP54-like NG domain (mutant)<br />
-**[[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
-**[[1kvn]], [[1kvv]] – AfSRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
-**[[2jqe]] – AfSRP54 M domain 313-433 – NMR<BR />
-**[[3dlu]], [[3dlv]], [[3dm5]] – SRP19 – ''Pyrococcus furiosus''<br />
-**[[1j8m]] – AaSPR GTPase domain – ''Acicianus ambivalens''<br />
-**[[1j8y]] – AaSPR GTPase domain (mutant)<br />
-**[[1qzx]] – SsSRP54 – ''Sulfolobus solfataricus''<br />
-*Signal recognition particle complexes with RNA
-**[[1e8o]], [[1e8s]], [[5aox]] - hSRP9 + hSRP14 + 7S RNA <br />
-**[[5m73]] - hSRP19 + hSRP68 + SRP72 + 7S RNA <br />
-**[[1ry1]] - hSRP9 + hSRP14 + hSRP19 + hSRP54 + 7S RNA<br />
-**[[4uyj]], [[4uyk]] - hSRP9 + hSRP14 + RNA<br />
-**[[1jid]] – hSRP19 + RNA<br />
-**[[3ktv]] - hSRP19 + RNA S domain<br />
-**[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
-**[[2j37]] - hSRP19 + SRP54 + ribosomal proteins L23, L31, L35 + RNA – Cryo EM<BR />
-**[[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
-**[[4ue5]] – dSRP9 + SRP14 + SRP54 + SRP68 + RNA – Cryo EM<br />
-**[[3ktw]] - SsSRP19 + RNA S domain <br />
-**[[1qzw]] – SsSRP + 7S RNA<br />
-**[[1lng]] – MjSRP19 + RNA – ''Methanocaldococcus jannaschii''<br />
-**[[1l9a]] - MjSRP19 (mutant) + RNA<br />
-**[[2v3c]], [[3ndb]], [[4xco]] - MjSRP19 + MjSRP54 + 7S RNA<br />
-**[[2iy3]] – TaSRP54-like + RNA - EM<BR />
-**[[1dul]], [[1hq1]], [[2pxp]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
-**[[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
-**[[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – Cryo EM<BR />
-**[[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA<br />
-**[[3zn8]] - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B<br />
-**[[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
-**[[2j28]] – EcSRP54-like + 70S ribosome  – Cryo EM<BR />
-**[[4ue4]] – SRP M domain + FtsQ signal sequence + RNA - ''Bacillus subtilis''<br />
-*Other signal recognition particle complexes
-**[[5l3q]], [[6y32]] – hSRP54 + SRP receptor subunit α<br />
-**[[3dep]] - AtSRP43 residues 85-267 + polypeptide<br />
-**[[5e4w]] - AtSRP43 chromodomain 2-3 + thioredoxin + ALB3 tail<br />
-**[[5l3r]] - AtSRP54 + cell division protein FTSY<br />
-**[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />
-**[[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
-**[[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FtsY<br />
-**[[2j7p]] - TaSRP54-like NG domain + cell division protein FtsY + GMPPNP<BR />
-**[[5l3s]] - SsSRP54 + cell division protein FtsY<br />
-**[[3kl4]] – SsSRP54 residues 2-432 + polypeptide<br />
-**[[5l3v]] - SsSRP54 + GDP<br />
-**[[4c7o]] – EcSRP + FtsY + SRP RNA<br />
-}}
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]