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| {{STRUCTURE_1e8o| PDB=1e8o | SIZE=400| SCENE= |right| CAPTION=Human SRP9+SRP14 complex with 7S RNA, GDP and sulfate [[1e8o]] }}
| | <StructureSection load='1e8o' size='350' side='right' scene='' caption='Human SRP9 (grey and pink) +SRP14 (green and yellow) complex with 7S RNA, GDP and sulfate [[1e8o]]'> |
| | '''Signal recognition particle''' (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the [[Signal recognition particle receptor|SRP receptor]]<ref>PMID:15718142</ref>. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14<ref>PMID:7542942</ref>, SRP19<ref>PMID:11682607</ref>, SRP54<ref>PMID:9511762</ref>, SRP68, SRP72<ref>PMID:8388879</ref> and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA. |
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| | ==3D structures of signal recognition particle== |
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| | [[Signal recognition particle 3D structures]] |
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| '''Signal recognition particle''' (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the SRP receptor. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14, SRP19, SRP54, SRP68, SRP72 and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.
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| ==3D structures of SRP== | |
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| [[1914]] – SRP9/SRP14 – mouse<br /> | |
| [[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
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| [[2ng1]] - TaSRP54-like NG domain (mutant)<br />
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| [[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
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| [[1kvn]], [[1kvv]] – SRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
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| [[1qb2]] – hSRP54 <br />
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| [[2hug]] – AtSRP43 chromo-2 domain + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
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| [[3deo]] - AtSRP43 residues 85-267<br />
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| [[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
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| [[3dlu]], [[3dlv]] – SRP19 – ''Pyrococcus furiosus''<br />
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| [[2w9j]] – SRP14 residues 1-91 – fission yeast
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| '''SRP complexes with RNA'''
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| [[1e8o]], [[1e8s]] - hSRP9 + hSRP14 + 7S RNA – human<br />
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| [[1ry1]] - hSRP9 + hSRP14 + hSRP19 + hSRP54 + 7S RNA<br />
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| [[1jid]] – hSRP19 + RNA<br />
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| [[3ktv]] - hSRP19 + RNA S domain<br />
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| [[3ktw]] - SRP19 + RNA S domain – ''Sulfolobus solfataricus''<br />
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| [[1lng]] – MjSRP19 + RNA – ''Methanocaldococcus jannaschii''<br />
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| [[1l9a]] - MjSRP19 (mutant) + RNA<br />
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| [[2v3c]], [[3ndb]] - MjSRP19 + MjSRP54 + 7S RNA<br />
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| [[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
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| [[2iy3]] – TaSRP54-like + RNA - EM<BR />
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| [[1dul]], [[1hq1]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
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| [[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
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| [[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – EM<BR />
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| [[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FTSY residues 196-497+ 4.5SRNA<br />
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| [[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
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| [[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
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| [[2j28]] – EcSRP54-like + 70S ribosome – EM<BR />
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| [[2j37]] - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM<BR />
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| '''Other SRP complexes'''
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| [[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />
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| [[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
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| [[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FTSY<br />
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| [[2j7p]] - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP<BR />
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| [[3dep]] - AtSRP43 residues 85-267 + polypeptide
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| | == References == |
| | <references/> |
| | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |