Severin: Difference between revisions

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[[Image:3fg6.png|left|200px]]
<StructureSection load='1svy' size='350' side='right' scene='41/410299/Cv/6' caption='Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions [[1svy]]' pspeed='8'>


{{STRUCTURE_3fg6|  PDB=3fg6  |  SCENE=Severin/Cv/1 |CAPTION=Severin, [[3fg6]] }}


'''3D Structure of Severin''' <br />
[[Severin]] is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins<ref>PMID:15060630</ref>. It is named Adseverin and Scinderin as well.


*<scene name='41/410299/Cv/9'>Ca coordination site</scene>. Water molecules are shown as red spheres.
*<scene name='41/410299/Cv/10'>Na coordination site</scene>.


== Actin Binding Protein ==
</StructureSection>
Severin is a calcium-activated protein which binds actin.  It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from [[Gelsolin]] (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a <scene name='Severin/Cv/2'>octamer</scene> (each monomer is colored in different colors) of the Severin with <scene name='Severin/Cv/3'>calcium ions</scene> (<font color='lime'><b>colored lime</b></font>).


== 3D Structures of Severin ==
== 3D Structures of Severin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3fg6]] – Adseverin C-terminal – human<br />
[[3fg6]] – Adseverin C-terminal – human<br />
[[1svy]] – Severin domain 2 – ''Dictyostelium discoideum'' <br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />
[[1svq]] - Severin domain 2 - ''Dictyostelium discoideum'', NMR<br />
[[1svq]], [[1svr]] - DdSeverin domain 2 - NMR<br />
== References ==
<references/>
[[Category:Topic Page]]

Latest revision as of 13:26, 19 November 2023


Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins[1]. It is named Adseverin and Scinderin as well.

  • . Water molecules are shown as red spheres.
  • .


Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions 1svy

Drag the structure with the mouse to rotate

3D Structures of Severin3D Structures of Severin

Updated on 19-November-2023

3fg6 – Adseverin C-terminal – human
1svy – DdSeverin domain 2 – Dictyostelium discoideum
1svq, 1svr - DdSeverin domain 2 - NMR

ReferencesReferences

  1. ↑ Summerscales J, Dawson JF. Probing Dictyostelium severin structure and function by cross linking to actin. Biochem Cell Biol. 2004 Apr;82(2):343-50. PMID:15060630 doi:http://dx.doi.org/10.1139/o04-002

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Alexander Berchansky, Michal Harel, Jaime Prilusky
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