5no6: Difference between revisions
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New page: '''Unreleased structure''' The entry 5no6 is ON HOLD until Paper Publication Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J. Description: TEAD4-HOXB13 complex bound ... |
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The | ==TEAD4-HOXB13 complex bound to DNA== | ||
<StructureSection load='5no6' size='340' side='right'caption='[[5no6]], [[Resolution|resolution]] 2.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5no6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NO6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5no6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5no6 OCA], [https://pdbe.org/5no6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5no6 RCSB], [https://www.ebi.ac.uk/pdbsum/5no6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5no6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TEAD4_HUMAN TEAD4_HUMAN] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref> | |||
==See Also== | |||
*[[Hox protein|Hox protein]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Taipale | [[Category: Large Structures]] | ||
[[Category: | [[Category: Jolma A]] | ||
[[Category: Morgunova E]] | |||
[[Category: Popov A]] | |||
[[Category: Taipale J]] | |||
[[Category: Yin Y]] | |||
Latest revision as of 16:14, 15 November 2023
TEAD4-HOXB13 complex bound to DNATEAD4-HOXB13 complex bound to DNA
Structural highlights
FunctionTEAD4_HUMAN Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.[1] [2] See AlsoReferences
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