5nfa: Difference between revisions

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<StructureSection load='5nfa' size='340' side='right'caption='[[5nfa]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='5nfa' size='340' side='right'caption='[[5nfa]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nfa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NFA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NFA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8VQ:~{N}-[(2~{R},3~{R},4~{R},5~{S},6~{R})-2-acetamido-6-(hydroxymethyl)-5-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-4-[(3-methoxyphenyl)methoxy]-3,5-bis(oxidanyl)oxan-2-yl]oxy-4-oxidanyl-oxan-3-yl]ethanamide'>8VQ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nf7|5nf7]], [[5nf9|5nf9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TVD:N-acetyl-2-(acetylamino)-2-deoxy-beta-D-glucopyranosylamine'>TVD</scene>, <scene name='pdbligand=TVM:3-O-[(3-methoxyphenyl)methyl]-beta-D-galactopyranose'>TVM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfa OCA], [https://pdbe.org/5nfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nfa RCSB], [https://www.ebi.ac.uk/pdbsum/5nfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfa OCA], [http://pdbe.org/5nfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfa RCSB], [http://www.ebi.ac.uk/pdbsum/5nfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Atmanene, C]]
[[Category: Atmanene C]]
[[Category: Ciesielski, F]]
[[Category: Ciesielski F]]
[[Category: Gautier, F M]]
[[Category: Djedaini Pilard F]]
[[Category: Grandjean, C]]
[[Category: Gautier FM]]
[[Category: Hannah, V Vivat]]
[[Category: Grandjean C]]
[[Category: Pilard, F Djedaini]]
[[Category: Ronin C]]
[[Category: Ronin, C]]
[[Category: Teletchea S]]
[[Category: Teletchea, S]]
[[Category: Vivat Hannah V]]
[[Category: Cation-pi interaction]]
[[Category: Galectin-3 crd]]
[[Category: Sugar binding protein]]

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