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==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25==
==Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25==
<StructureSection load='6a96' size='340' side='right' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
<SX load='6a96' size='340' side='right' viewer='molstar' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [http://pdbe.org/6a96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [http://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [https://pdbe.org/6a96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [https://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
[https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
 
==See Also==
*[[GABA receptor 3D structures|GABA receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Bi, G Q]]
[[Category: Homo sapiens]]
[[Category: Cui, Y]]
[[Category: Lama glama]]
[[Category: Guan, F]]
[[Category: Large Structures]]
[[Category: Liu, S]]
[[Category: Bi GQ]]
[[Category: Liu, Y T]]
[[Category: Cui Y]]
[[Category: Xu, L]]
[[Category: Guan F]]
[[Category: Ye, S]]
[[Category: Liu S]]
[[Category: Zhang, Q]]
[[Category: Liu YT]]
[[Category: Zhang, X]]
[[Category: Xu L]]
[[Category: Zhou, Z H]]
[[Category: Ye S]]
[[Category: Iron channel]]
[[Category: Zhang Q]]
[[Category: Membrane protein]]
[[Category: Zhang X]]
[[Category: Zhou ZH]]

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