5qgo: Difference between revisions
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==PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220== | |||
<StructureSection load='5qgo' size='340' side='right'caption='[[5qgo]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5qgo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QGO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H4A:(3aR,4R,6R,7R,8aR)-6-phenyloctahydro-1H-3a,7-epiminocyclohepta[c]pyrrol-4-ol'>H4A</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgo OCA], [https://pdbe.org/5qgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qgo RCSB], [https://www.ebi.ac.uk/pdbsum/5qgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgo ProSAT]</span></td></tr> | ||
[[Category: Aimon | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). | ||
[[Category: | __TOC__ | ||
[[Category: Brandao-Neto | </StructureSection> | ||
[[Category: Diaz Saez | [[Category: Homo sapiens]] | ||
[[Category: Fairhead | [[Category: Large Structures]] | ||
[[Category: | [[Category: Aimon A]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Bradley AR]] | ||
[[Category: | [[Category: Brandao-Neto J]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Collins P]] | ||
[[Category: | [[Category: Diaz Saez L]] | ||
[[Category: | [[Category: Douangamath A]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: Elkins J]] | |||
[[Category: Fairhead M]] | |||
[[Category: Huber K]] | |||
[[Category: Krojer T]] | |||
[[Category: London N]] | |||
[[Category: Nelson A]] | |||
[[Category: Ruda GF]] | |||
[[Category: Spencer J]] | |||
[[Category: Srikannathasan V]] | |||
[[Category: Szommer T]] | |||
[[Category: Talon R]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 12:54, 15 November 2023
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220
Structural highlights
FunctionNUDT7_HUMAN Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). |
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