4gm9: Difference between revisions

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-{{STRUCTURE_4gm9|  PDB=4gm9  |  SCENE=  }}
-===Crystal structure of human WD repeat domain 5 with compound MM-401===
-==Function==
+==Crystal structure of human WD repeat domain 5 with compound MM-401==
-[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
+<StructureSection load='4gm9' size='340' side='right'caption='[[4gm9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4gm9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GM9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XO:2-METHYL-D-LYSINE'>0XO</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=ALQ:2-METHYL-PROPIONIC+ACID'>ALQ</scene>, <scene name='pdbligand=PG9:D-PHENYLGLYCINE'>PG9</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gm9 OCA], [https://pdbe.org/4gm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gm9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gm9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
-==About this Structure==
+==See Also==
-[[4gm9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GM9 OCA].
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
+== References ==
-==Reference==
+<references/>
-<references group="xtra"/><references/>
+__TOC__
-[[Category: Bernard, D.]]
+</StructureSection>
-[[Category: Chen, Y.]]
+[[Category: Homo sapiens]]
-[[Category: Dou, Y.]]
+[[Category: Large Structures]]
-[[Category: Karatas, H.]]
+[[Category: Bernard D]]
-[[Category: Lei, M.]]
+[[Category: Chen Y]]
-[[Category: Liu, L.]]
+[[Category: Dou Y]]
-[[Category: Townsend, E C.]]
+[[Category: Karatas H]]
-[[Category: Wang, S]]
+[[Category: Lei M]]
-[[Category: Histone methyltransferase]]
+[[Category: Liu L]]
-[[Category: Mll1]]
+[[Category: Townsend EC]]
-[[Category: Transcription-transcription inhibitor complex]]
+[[Category: Wang S]]
-[[Category: Wd40]]