4a1u: Difference between revisions

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 ==Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL==
-<StructureSection load='4a1u' size='340' side='right' caption='[[4a1u]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
+<StructureSection load='4a1u' size='340' side='right'caption='[[4a1u]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a1u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A1U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a1u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A1U FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene>, <scene name='pdbligand=HT7:(3S)-3-AMINO-4-(1H-INDOL-3-YL)BUTANOIC+ACID'>HT7</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HR7:(3S)-3-AMINO-6-[(DIAMINOMETHYLIDENE)AMINO]HEXANOIC+ACID'>HR7</scene>, <scene name='pdbligand=HT7:(3S)-3-AMINO-4-(1H-INDOL-3-YL)BUTANOIC+ACID'>HT7</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bxl|1bxl]], [[4a1w|4a1w]], [[1ysi|1ysi]], [[2yj1|2yj1]], [[2b48|2b48]], [[1r2e|1r2e]], [[1ysn|1ysn]], [[1ysg|1ysg]], [[1r2g|1r2g]], [[1r2h|1r2h]], [[1lxl|1lxl]], [[1r2d|1r2d]], [[1g5j|1g5j]], [[1maz|1maz]], [[1r2i|1r2i]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1u OCA], [https://pdbe.org/4a1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a1u RCSB], [https://www.ebi.ac.uk/pdbsum/4a1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1u ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a1u OCA], [http://pdbe.org/4a1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a1u RCSB], [http://www.ebi.ac.uk/pdbsum/4a1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a1u ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
+[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 </div>
 <div class="pdbe-citations 4a1u" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Boersma, M D]]
+[[Category: Large Structures]]
-[[Category: Clarke, O B]]
+[[Category: Synthetic construct]]
-[[Category: Colman, P M]]
+[[Category: Boersma MD]]
-[[Category: Fairlie, W D]]
+[[Category: Clarke OB]]
-[[Category: Gellman, S H]]
+[[Category: Colman PM]]
-[[Category: Haase, H S]]
+[[Category: Fairlie WD]]
-[[Category: Horne, W S]]
+[[Category: Gellman SH]]
-[[Category: Kaufman, K J]]
+[[Category: Haase HS]]
-[[Category: Lee, E F]]
+[[Category: Horne WS]]
-[[Category: Smith, B J]]
+[[Category: Kaufman KJ]]
-[[Category: Alpha-helix]]
+[[Category: Lee EF]]
-[[Category: Apoptosis]]
+[[Category: Smith BJ]]
-[[Category: Bh3]]
-[[Category: Mimicry]]