Sequestosome: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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 == Structural highlights ==
 SQS is a multi-domain protein.  SQS domain structure includes: <br />
-PB1 domain which contains Phox and Berm1<br />
+*PB1 domain which contains Phox and Berm1<br />
-ZZ-type zinc finger <br />
+*ZZ-type zinc finger <br />
-SMIR – SOD interaction domain<br />
+*SMIR – SOD interaction domain<br />
-TB – TRAF6 binding motif<br />
+*TB – TRAF6 binding motif<br />
-LC3 – microtubule-associated protein 1 light chain 3B<br />
+*LC3 – microtubule-associated protein 1 light chain 3B<br />
-LIR – interaction region<br />
+*LIR – interaction region<br />
-UBA – ubiquitin association domain.
+*UBA – ubiquitin association domain.
 == Relevance ==
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – SQS UBA domain – human - NMR<br />
+Domains: PB1 1-102; ZZ 120-180; UBA 387-436
-[[3b0f]] – mSQS UBA domain – mouse <br />
-[[2rru]] – mSQS UBA domain - NMR<br />
+[[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – hSQS UBA domain – human - NMR<br />
+[[6jm4]] – hSQS-1 PB1 domain (mutant)<br />
+[[4uf8]], [[4uf9]], [[6tgy]], [[6th3]] – hSQS-1 PB1 domain – Cryo EM<br />
+[[5yp7]], [[5yp8]], [[5ypa]], [[5ypb]], [[5ypc]], [[5ype]], [[5ypg]], [[5yph]], [[5ypi]], [[6miu]] – hSQS-1 ZZ domain<br />
+[[6mj7]] – hSQS-1 ZZ domain + Arg<br />
+[[6khz]] – hSQS-1 ZZ domain + Gly<br />
+[[7r1o]] – hSQS-1 ZZ domain + drug<br />
 [[2ktr]] – rSQS PB1 domain – rat - NMR<br />
 [[2kkc]] – rSQS PB1 domain (mutant) - NMR<br />
-[[3ade]] – mSQS + KEAP-1 – mouse<br />
 [[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br />
-[[4uf8]], [[4uf9]] – hSQS-1 PB1-P62 domain – Cryo EM<br />
+[[3b0f]] – mSQS UBA domain – mouse <br />
+[[2rru]] – mSQS UBA domain - NMR<br />